pot-1 Antibody
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pot-1 antibody; CeOB2 antibody; B0280.10 antibody; Protection of telomeres homolog 1 antibody
Target Names
pot-1
Uniprot No.
Target Background
Function
Pot-1 Antibody targets a telomeric DNA-binding protein that exhibits high specificity for single-stranded C-rich repeat sequences, particularly the 5'-GCCTAA-3' sequence. This binding can occur at either the 5' or 3' telomeric end. Pot-1 plays a crucial role in safeguarding the 5' end of the C-rich strand within the telomere. It acts redundantly with Pot-2 to negatively regulate telomere extension mediated by telomerase. Additionally, Pot-1 regulates telomere length through the alternative lengthening of telomeres (ALT) pathway, an independent mechanism from telomerase. Through its interaction with Sun-1, Pot-1 anchors telomeres to the nuclear envelope in embryonic development.
Database Links
Subcellular Location
Nucleus. Nucleus envelope. Chromosome, telomere.
Tissue Specificity
Expressed in sperm and oocytes.
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