POT5 Antibody
Description
Absence of "POT5 Antibody" in Available Data
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Search Result Review: None of the 13 provided sources, including antibody databases ( ), research articles ( ), and commercial antibody catalogs ( ), reference a "POT5 Antibody."
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Scientific Validity: The term "POT5" does not correspond to any recognized protein, gene, or antibody target in standard repositories such as UniProt, GenBank, or the Human Protein Atlas.
Potential Confusion with "POT1 Antibody"
The search results extensively describe POT1 (Protection of Telomeres 1), a telomere-associated protein, and antibodies targeting it. Misidentification may stem from typographical errors or nomenclature overlaps.
Key Data on POT1 Antibodies
Research Findings for POT1
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POT1 deficiency correlates with telomere dysfunction and cancer susceptibility .
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Antibodies against POT1 enable studies on telomerase RNP complex dynamics .
Hypothetical Considerations for "POT5"
If "POT5" refers to an uncharacterized or emerging target, the following steps are critical for validation:
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Sequence Alignment: Confirm homology to known telomere-associated proteins (e.g., POT1, POT2).
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Antibody Specificity: Validate using knockout cell lines or siRNA silencing.
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Functional Assays: Assess roles in telomere maintenance or disease pathways.
Recommendations for Clarification
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Typographical Verification: Confirm whether the query refers to POT1 or another established target.
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Literature Update: Explore recent preprints or patents post-2023 for novel "POT5" references.
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Antibody Validation: If targeting a new epitope, follow guidelines from antibody characterization initiatives ( ).
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Research indicates that ARF2 plays a crucial role in the response to external potassium (K+) supply in Arabidopsis and regulates HAK5 transcription accordingly. PMID: 27895227
- ILK1 interacts with and promotes the accumulation of HAK5, a putative (H+)/K+ symporter that facilitates high-affinity uptake during potassium deficiency. PMID: 27208244
- Data reveals that Arabidopsis mutants lacking CBL-interacting protein kinase23 (CIPK23) exhibit deficiencies in high-affinity K+ transporter5 (HAK5)-mediated high-affinity potassium (K+) uptake. PMID: 26474642
- Findings suggest that there is a posttranscriptional regulation of HAK5 triggered by the low K+ signal, and that HAK5 may be involved in yet-unidentified functions related to nitrate (NO3-) and phosphate (P) deficiencies. PMID: 24716623
- The absence of ETO1 function leads to a significant enhancement of tissue potassium status through an RBOHF-independent mechanism associated with elevated high-affinity K+ TRANSPORTER5 transcript levels. PMID: 24064768
- HAK5 and four transcription factor genes, DDF2, JLO, bHLH121, and TFII_A, were found to be highly up-regulated in response to both potassium deficiency and salt stress. PMID: 23825216
- Despite having a limited capacity, AtHAK5 plays a significant role in potassium acquisition from low potassium concentrations in the presence of salinity. PMID: 20028724
- Research suggests that RCI3 is involved in the production of reactive oxygen species (ROS) under potassium deprivation, and that RCI3-mediated ROS production influences the regulation of AtHAK5 expression. PMID: 20139158
- AtHAK5 is the sole system responsible for potassium uptake at concentrations below 0.01 mM. In the range between 0.01 and 0.05 mM potassium, AtHAK5 and AtAKT1 are the primary contributors to potassium acquisition. PMID: 20088908
- Up-regulation of the HAK5 protein in response to potassium deprivation has been observed in Arabidopsis thaliana. PMID: 15734909
- AtHAK5 functions as a root plasma membrane uptake mechanism for potassium and cesium under conditions of low potassium availability. PMID: 18281719
- AtHAK5 mediates potassium absorption at low concentrations more effectively than AtAKT1. The induction of AtHAK5 is repressed by ammonium (NH4+). PMID: 19000196
