pph-4.1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pph-4.1 antibody; Y75B8A.30 antibody; Serine/threonine-protein phosphatase 4 catalytic subunit 1 antibody; PP4C-1 antibody; EC 3.1.3.16 antibody
Target Names
pph-4.1
Uniprot No.
Target Background
Function
Protein phosphatase PPH-4.1 plays a crucial role in both meiosis and early embryonic mitosis. During spermatocyte meiosis and the initial stages of embryonic mitosis, it regulates centrosome maturation, ultimately impacting spindle formation through the recruitment of pericentriolar material (PCM) components. During oocyte meiosis I, PPH-4.1 regulates meiotic chromosome dynamics, including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation, and crossover formation leading to chiasma formation. In oocyte meiosis II, PPH-4.1, possibly in conjunction with the regulatory subunit ppfr-1, may regulate microtubule severing by dephosphorylating and activating mei-1, a component of the katanin microtubule severing complex.
Gene References Into Functions
- Research in *Caenorhabditis elegans* demonstrates that PPH-4.1 is essential for executing four distinct functions related to meiotic chromosome dynamics. PMID: 25340746
Database Links
Protein Families
PPP phosphatase family, PP-4 (PP-X) subfamily
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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