PPARA Antibody

1. Ubiquitination modification, mediated by the coordinated action of PAQR3 and HUWE1, plays a crucial role in regulating the activity of hepatic PPARα in response to starvation. PMID: 29331071
2. Circulated eosinophilic expression of PPARα protein is reduced in metabolic syndrome. PMID: 29699951
3. TNFα differentially regulates the levels of PPARα, LXRα, and LXRβ binding to the apoA-I gene promoter in THP-1 cells. These findings suggest a novel tissue-specific mechanism for TNFα-mediated regulation of the apoA-I gene in monocytes and macrophages and demonstrate that endogenous ApoA-I may be positively regulated in macrophages during inflammation. PMID: 29442267
4. MAR1 ameliorates LPS-induced atherosclerotic reactions via PPARα-mediated suppression of inflammation and ER stress. PMID: 29971543
5. Data suggest that, in hepatocytes, MIRN34A plays a role in regulating mitochondrial remodeling and lipid metabolism, including the development/prevention of non-alcoholic fatty liver disease. MIRN34A appears to act via the AMPK/PPARα signal transduction pathway. (MIRN34A = microRNA 34a; AMPK = AMP-activated protein kinase; PPARα = peroxisome proliferator activated receptor alpha) PMID: 29197627
6. miR-214 overexpression inhibits glioma cell growth in vitro and in vivo by inducing cell cycle arrest in G0/G1. These data collectively uncover a novel role for a PPARα-miR-214-E2F2 pathway in controlling glioma cell proliferation. PMID: 29862267
7. Improvements in metabolic and neurodegenerative diseases are often attributed to anti-inflammatory effects of PPAR activation. (Review) PMID: 29799467
8. circRNA_0046366, which demonstrates expression loss in HepG2-based hepatocellular steatosis, exerts an antagonistic effect on miR-34a activity. miR-34a inactivation abrogates its inhibitory role against PPARα. PMID: 29391755
9. We first reported that the FOMX1 pathway is the most upregulated and the PPARα pathway is the most downregulated pathway in Triple Negative Breast Cancers (TNBCs). These two pathways could be simultaneously targeted in further studies. The pathway classifier performed in this study also provides insight into the heterogeneity of TNBCs. PMID: 29301506
10. Polymorphism of PPARA is associated with late onset of type 2 diabetes mellitus. PMID: 28292576
11. Results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARα signaling, inhibiting the TLR4-mediated NF-κB signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4/ERK1/2/AP-1/STAT3), suggesting that OEA may be a therapeutic agent for inflammatory diseases. PMID: 27721381
12. Data suggested that miR-19a negatively controlled the autophagy of hepatocytes attenuated in D-GalN/LPS-stimulated hepatocytes via regulating NBR2 and AMPK/PPARα signaling. PMID: 28586153
13. The minor allele of rs1800206 and rs1805192 from PPAR A and PPAR G and its interaction were associated with increased Breast Cancer risk. PMID: 28669518
14. High concentrations of DINCH urinary metabolites activate human PPAR-α. PMID: 29421333
15. PPARα is overexpressed in primary glioblastoma PMID: 27926792
16. These results suggest that the E2F1/miR19a/PPARα feedback loop is critical for glioma progression PMID: 27835866
17. Data conclude that the ER-stress mediated reduction in apoA-I transcription could be partly mediated via the inhibition of PPARα mRNA expression and activity. In addition, BET inhibition increased apoA-I transcription, even if PPARα production and activity were decreased. Both BET inhibition and PPARα activation ameliorate the apoA-I lowering effect of ER-stress and are therefore interesting targets to elevate... PMID: 28012209
18. Results demonstrated that PPARα directly inhibited Glut1 mRNA expression resulting in influx of glucose in cancer cells. PMID: 27918085
19. PPARα and LXRα may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury PMID: 26756785
20. Our results support an important association between rs1800206 minor allele of PPAR alpha and diabetic retinopathy, and the interaction analysis also shown a combined effect of Leu162 allele-abdominal obesity interaction on diabetic retinopathy. PMID: 26671228
21. Taken together, our data suggest that eupatilin inhibits TNFα-induced MMP-2/-9 expression by suppressing NF-κB and MAPKAP-1 pathways via PPARα. Our findings suggest the usefulness of eupatilin for preventing skin aging. PMID: 28899779
22. Hepatic PARP1 activation inhibits FAO pathway upregulation through poly(ADP-ribosyl)ation of PPARα, worsening hepatic steatosis and inflammatory responses associated with overnutrition. PMID: 27979751
23. Aleglitazar protects cardiomyocytes against hyperglycemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma. PMID: 28111985
24. Study reports a molecular mechanism by which glucocorticoid-induced PPARα expression negatively affects the activity of PPARγ and downregulates BCO1 gene expression. Results explicate novel aspects of local glucocorticoid:retinoid interactions that may contribute to alveolar tissue remodeling in chronic lung diseases that affect children and, possibly, adults. PMID: 28732066
25. Interference with PLIN2 and PPARα resulted in major alterations in gene expression, especially affecting lipid, glucose, and purine metabolism. PMID: 27308945
26. PPARα and FXR function coordinately to integrate liver energy balance. PMID: 28287408
27. This study showed that oleoylethanolamine and palmitoylethanolamine have endogenous roles and potential therapeutic applications in conditions of intestinal hyperpermeability and inflammation. PMID: 27623929
28. An association was found with PPARα polymorphism and patients with nicotine dependency and schizophrenia. PMID: 27624431
29. PPAR agonists have shown to have anti-proliferative effects in squamous cell carcinoma of the head and neck. PMID: 27896820
30. Results show that PPARα is downregulated and SREBP-1c is upregulated in steatosis L-02 cells. These changes increase lipid synthesis and reduce lipid disposal, ultimately leading to hepatic steatosis. PMID: 27270405
31. Perfluoroalkyl acids, in addition to activating PPARα as a primary target, also have the potential to activate CAR, PPARγ, and ERα, as well as suppress STAT5B. PMID: 28558994
32. The metabolic events controlled by PPARs, occurring during neuronal precursor differentiation, particularly glucose and lipid metabolism, were investigated. PMID: 27860527
33. The CYP2E1-PPARα axis may play a role in ethanol-induced neurotoxicity via the alteration of genes related to synaptic function PMID: 28385499
34. Studies indicate that natural dietary compounds, including nutrients and phytochemicals, are Peroxisome proliferator-activated receptor alpha (PPARα) ligands or modulators. PMID: 27863018
35. Genome-wide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR, and PPARα in primary human hepatocytes has been presented. PMID: 26994748
36. Hepatitis B virus increases the expression of α-mannosidases both in vitro and in vivo via activation of the PPARα pathway by its envelope protein. PMID: 27920474
37. These observations candidate PPARs as new biomarkers of follicle competence, opening new hypotheses on controlled ovarian stimulation effects on ovarian physiology. PMID: 26332656
38. PPARα activation plays defensive and compensative roles by reducing cellular toxicity associated with fatty acids and sulfuric acid. PMID: 27644403
39. PPARα/γ agonist, elafibranor resolves nonalcoholic steatohepatitis without worsening fibrosis. PMID: 26874076
40. The effects of fenofibrate on nonalcoholic fatty liver disease in the context of PPAR-α activation were studied. PMID: 27930988
41. PPARA polymorphism is associated with the risk of coronary heart disease. PMID: 27512842
42. Telmisartan improved the hyperglycemia-induced cardiac fibrosis through the PPARδ/STAT3 pathway. PMID: 27519769
43. A modest relationship was found between PPARα and AIP expression, both being significantly higher in the presence of pre-operative somatostatin analogues in somatotropinoma patients. PMID: 26872613
44. Fenofibrate inhibited atrial metabolic remodeling in atrial fibrillation (AF) by regulating the PPAR-α/sirtuin 1/PGC-1α pathway, indicating a novel therapeutic strategy for AF PMID: 26787506
45. PPAR delta + 294TT genotype frequency in the Chinese Han population was higher than in the Chinese Uyghur population and may affect the risk of ischemic stroke. PMID: 26814631
46. PPARα functions as an E3 ubiquitin ligase to induce Bcl2 ubiquitination and degradation, leading to increased cancer cell sensitivity in response to chemotherapy drugs. PMID: 26556865
47. There was no statistically significant difference in the distribution of PPARα Leu162Val polymorphism between the ischemic stroke patients and controls in the Han ethnic group. PMID: 26671025
48. Results support an important association between rs1800206 minor allele (V) of PPAR alpha and lower CRP level; the interaction analysis showed a combined effect between rs1800206 and rs135539 on the lower CRP level PMID: 26497374
49. PPAR-γ and PTEN expressions are related to the clinical parameters and prognosis of renal cell carcinoma PMID: 26722456
50. Describe a renoprotective role of fenofibrate in albumin bound fatty acid associated tubular toxicity, involving the transcriptional activation of PPARα and suppression of NF-kB. PMID: 26617775

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HGNC: 9232

OMIM: 170998

KEGG: hsa:5465

STRING: 9606.ENSP00000262735

UniGene: Hs.103110