pph-6 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 week lead time (made-to-order)
Synonyms
pph-6 antibody; C34C12.3 antibody; Serine/threonine-protein phosphatase 6 catalytic subunit antibody; EC 3.1.3.16 antibody; Protein phosphatase pph-6 antibody
Target Names
pph-6
Uniprot No.
Target Background
Function
The pph-6 antibody targets the catalytic subunit of protein phosphatase 6 (PP6). In conjunction with SAPS-1, it promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II (nmy-2), thus ensuring accurate spindle positioning. Furthermore, pph-6 is essential for generating the forces required to pull spindle poles during anaphase, achieved by regulating the cortical localization of GPR-1, GPR-2, and LIN-5.
Gene References Into Functions
- The PPH-6/SAPS-1 complex is crucial for actomyosin network contractility and proper spindle positioning. PMID: 20040490
Database Links
Protein Families
PPP phosphatase family, PP-X subfamily
Subcellular Location
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole.
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