PPM1D Antibody

1. Research suggests a novel role for ATR kinase in mediating its own signal attenuation by recruiting PPM1D to chromatin. This mechanism is critical for restarting stalled replication forks, cell cycle re-entry, and cellular recovery from replication stress. PMID: 29485113
2. NF-kappaB acts as a positive transcriptional regulator of WIP1, activating its expression and influencing its function in colorectal cancer cells. PMID: 29367109
3. These findings provide insights into the molecular mechanisms governing nucleoli formation. The study demonstrates that PPM1D regulates nucleolar formation by modulating NPM phosphorylation status through a novel signaling pathway involving PPM1D-CDC25C-CDK1-PLK1. PMID: 27619510
4. These data support the notion that Wip1 contributes to the formation of ERMs in PDR membranes via NF-kappaB signaling. PMID: 28402943
5. In an in vitro model of the blood-brain barrier, LPS increased Wip1 expression. Wip1 knockdown led to increased permeability, decreased transepithelial electrical resistance, reduced protein expression of ZO-1 and occluding, and enhanced TNF-alpha, IL-1beta, IL-12, and IL-6 production. Wip1 silencing augmented Sonic hedgehog signaling, while Wip1 overexpression inhibited it. These findings suggest that Wip1 may protect the BBB against LPS damage through SHH signaling. PMID: 29128669
6. Studies suggest a role for Wip1 in tumorigenesis through regulation of the p53 and p38MAPK pathways. PMID: 26883196
7. Inhibition of Wip1 may enhance p53-mediated tumor suppression by Mdm2 antagonists. PMID: 27183917
8. Wip1 suppressed ovarian cancer cell invasion, migration, epithelial-to-mesenchymal transition (EMT), and ovarian cancer metastasis in xenograft animal models. PMID: 27121065
9. This model reproduces the observed cellular phenotypes in experiments: oscillatory (for low DNA damage) regulated by negative feedback loops involving mainly p53 and Mdm2, and apoptotic or senescent (for high DNA damage) regulated by the positive p53/Wip1/miR-16 feedback loop. PMID: 28968438
10. These findings suggest an important crosstalk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for medulloblastoma. PMID: 27086929
11. Wip1 activity and its relevance to cancer as an oncoprotein are reviewed. PMID: 28385459
12. The authors demonstrate that a global spread of ATM activity on chromatin and phosphorylation of ATM targets, including KAP1, control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, enabling cell cycle restart despite persistent ATM activity present at DNA lesions. PMID: 28607002
13. Truncating and missense PPM1D mutations are associated with prostate cancer. PMID: 27401275
14. This study reveals decreased expression of Wip1 in patients with active inflammatory bowel disease. PMID: 27687530
15. Wip1 is frequently overexpressed in non-small cell lung cancer, potentially playing a crucial role in the p38MAPK/p53/p16 signaling pathway. PMID: 27959454
16. This study identified 14 individuals with mild to severe intellectual disability (ID) or developmental delay and de novo truncating PPM1D mutations. All mutations were located in the last or penultimate exon, suggesting escape from nonsense-mediated mRNA decay. PMID: 28343630
17. PPM1D gene silencing combined with TMZ eradicates glioma cells through cell apoptosis and cell cycle arrest. PMID: 27633132
18. High PPM1D expression is associated with breast cancer. PMID: 27485113
19. PPM1D in the chromosomal location 17q22-24 may be the most relevant candidate gene with respect to a potential functional implication in meningioma progression. PMID: 26942600
20. PPM1D is a potential prognostic marker and therapeutic target for hepatocellular carcinoma. PMID: 26809466
21. PPM1D suppresses pancreatic cancer cell apoptosis via inhibition of the p38 MAPK/p53 pathway through both dephosphorylation of p38 MAPK and downregulation of ASPP2. PMID: 26714478
22. Squalene inhibits the ATM-dependent signaling pathway following DNA damage through intracellular induction of Wip1 expression. PMID: 26824362
23. Chemotherapy exposure and age influence the accumulation of PPM1D mutations in the peripheral blood mononuclear cells of ovarian cancer patients. PMID: 26847329
24. Knockdown of Wip1 enhances sensitivity to radiation in HeLa cells by inhibiting cell proliferation and inducing apoptosis through activation of p38 MAPK. PMID: 26351212
25. Results showed evidence that Wip1 underwent Cdh1-dependent proteolysis during mitosis, and sustained Wip1 activity during mitosis resulted in mitotic delay at the metaphase to anaphase transition. PMID: 25649870
26. This study reveals a mechanism of stem cell aging, in which distinct effects of the p53 and mTORC1 pathways on HSC aging are governed by Wip1. PMID: 25879755
27. WIP1 silencing reduced expression of MMP-9, VEGF-C, cyclin D1, and c-Myc, as well as migration and invasion of salivary adenoid cystic carcinoma cells. WIP1 expression was positively associated with ACC metastasis and prognosis. PMID: 25797250
28. Wip1 may be involved in the biological processes of nasopharyngeal cancer cell proliferation, apoptosis, and migration and invasion. PMID: 25060857
29. p21 may contribute to the positive regulation of WIP1, leading to the dephosphorylation of the histone H2A variant gammaH2AX. PMID: 26006237
30. PPM1D plays an important role in promoting CDDP resistance. PMID: 25154814
31. Data suggests that WIP1 inhibition represents a novel therapeutic approach to neuroblastoma that could be integrated with current chemotherapeutic approaches. PMID: 25658463
32. ATM kinase and Wip1 phosphatase were identified as opposing regulators of DAXX-S564 phosphorylation. The role of DAXX phosphorylation and DAXX itself are independent of p53-mediated gene expression. PMID: 25659035
33. Wip1 protein was increased in kidney carcinoma. PMID: 24970693
34. Results show that downregulation of HIPK2 increases resistance of bladder cancer cells to cisplatin by regulating Wip1. PMID: 24846322
35. PPM1D plays an important role in the progression of NSCLC. PMID: 25412952
36. High PPM1D expression is associated with lung cancer. PMID: 25123458
37. Truncating mutations of PPM1D are present in blood DNA of NSCLC patients. PMID: 25742468
38. Results demonstrate increased WIP1 expression in metastatic medulloblastomas, and inferior survival in patients with WIP1 high-expressing medulloblastoma. PMID: 24632620
39. WIP1 knockdown inhibited the invasiveness of CNE-2 and 5-8F cells and was associated with the down-regulation of the expression of matrix metallopeptidase 9. PMID: 24801909
40. Gain-of-function PPM1D mutations are associated with brainstem gliomas. PMID: 24880341
41. High PPM1D expression is associated with prostate cancer. PMID: 24922655
42. PP4 and Wip1 are differentially required to counteract the p53-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53-mediated responses, respectively. PMID: 24711418
43. Wip1 may be involved in the biological processes of non-small cell lung cancer cell proliferation, cell apoptosis, and cell cycle. PMID: 24272082
44. PPM1D plays a crucial role in colorectal carcinoma cell proliferation and colony formation. PMID: 23745790
45. PPM1D mutations in the mosaic state predispose women to breast and ovarian cancer in the absence of a family history of cancer. PMID: 24262437
46. Expression of Wip1 in neutrophils was downregulated quickly after neutrophil activation through the JNK-microRNA-16 pathway. It was negatively correlated with inflammatory cytokine productions of neutrophils in sepsis patients. PMID: 24395919
47. Genetic variants and mutations of PPM1D control the response to DNA damage. PMID: 23907125
48. BAX dephosphorylation of Wip1 phosphatase is an important regulator of resistance to anticancer therapy. PMID: 23907458
49. High WIP1 expression is associated with colorectal cancer. PMID: 23679302
50. Wip1 plays an important role in the regulation of global heterochromatin silencing and thus is critical in maintaining genome integrity. PMID: 24135283

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HGNC: 9277

OMIM: 114480

KEGG: hsa:8493

STRING: 9606.ENSP00000306682

UniGene: Hs.286073