PPP2R1A Antibody

• PP2A regulates mitotic exit through EG5 dephosphorylation. PMID: 28487562
• Overexpression of PPP2R1A-WT leads to a significant increase in both total PP2A activity and PPP2R1A-associated PP2Ac activity. Additionally, overexpression of PPP2R1A-WT enhances cell proliferation in vitro and tumor growth in vivo. PMID: 27272709
• Mutations in PPP2R1A are found in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential, leading to decreased disease-free survival and overall survival. PMID: 27469332
• Studies have shown that the stimulatory effect of eEF-2K on glycolysis is a result of the kinase-mediated inhibition of the synthesis of the protein phosphatase 2A-A (PP2A-A). PMID: 27181208
• PPP2R1A mutations are linked to endometrial carcinoma progression and abdominopelvic metastasis. PMID: 27348297
• PPP2R1A mutations impact PP2A function and oncogenic signaling, providing insights into the genetic basis for serous EC development. PMID: 27485451
• Phosphorylation of PR65A regulates PP2A complex signaling. PMID: 24465463
• Research suggests that IH-induced ROS generation increases PP2A activation, subsequently downregulating ERK1/2 activation. This leads to the inhibition of PC12 cell proliferation through G0/G1 phase arrest and NGF-induced neuronal differentiation. PMID: 24885237
• Two functional variants in PPP2R1A and PPP2R5E, and their combinations, are associated with lung cancer risk in the Chinese population. PMID: 24204789
• Partial unfolding of PR65/A affects catalysis by altering the proximity of the bound catalytic subunit and substrate. PMID: 24120762
• A heterozygous, somatic mutation (c.771G>T, p.W257C) in PPP2R1A was identified in one out of 37 patients (2.7%) with primary ovarian endometrioid carcinoma. PMID: 23588898
• Gene transcription of PPP2R1A is regulated by the polymorphism and methylation in the promoter region. PMID: 23555712
• This study indicates that PPP2R1A mutations occur at a lower frequency compared to other gynecological malignancies, regardless of the histological subtype. PMID: 23267135
• There is a frequent mutation of PPP2R1A in the serous type of uterine cancer, a low frequency of mutation in endometrioid endometrial cancer, and no mutation in uterine carcinosarcoma. PMID: 21882256
• Research suggests that functional genetic variants in the proximal promoter of the PP2A-Aalpha gene and their haplotypes are crucial in the regulation of transcriptional activation. PMID: 21889517
• Somatic missense mutations have been identified in 40.8% of high-grade serous endometrial tumors and 5% of endometrial endometrioid carcinomas. Mutations were identified in ovarian tumors at lower frequencies, and no mutations were found in high- or low-grade serous carcinoma. PMID: 21381030
• PPP2R1A somatic mutations occur in certain types of uterine and ovarian neoplastic lesions, particularly uterine serous carcinomas. PMID: 21435433
• PP2A-mediated dephosphorylation of Carma1 is a crucial step in limiting T-cell activation and effector cytokine production. PMID: 21157432
• Genes mutated in ovarian clear cell carcinoma (OCCC) provide evidence that PPP2R1A acts as an oncogene and ARID1A as a tumor-suppressor gene. In 42 OCCCs, 7% had mutations in PPP2R1A and 57% in ARID1A, suggesting that aberrant chromatin remodeling contributes to OCCC. PMID: 20826764
• Studies demonstrate that under hypoxic conditions, TGF-beta-induced phosphorylation of Smad3 is inhibited, while Smad2 remains phosphorylated. Smad3 is dephosphorylated by PP2A. PMID: 19951945
• PP2A-A alpha transcriptional regulation is influenced by various factors, including AP-2alpha, CREB, ETS-1, and SP-1. PMID: 19750005
• Data reveals that DSB promotes PP2A association with Ku 70 and Ku 86. PMID: 19794960
• PP2A-A plays a role in the failure of beta1 integrin dephosphorylation at threonines 788 and 789 in tumor cell lines. PMID: 14532964
• PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress. PMID: 16717086
• Dysfunction of E-cadherin due to its endocytosis may occur in a proportion of human breast carcinomas where the PP2A-A protein is lost or significantly reduced. PMID: 16930554
• Protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator is regulated by heptad repeats, which are targeted by HTLV-I tax. PMID: 17314097
• Experimental findings indicate that the HSF2 region encompassing amino acids 343-363 is crucial for A subunit interaction. PMID: 17688198

HGNC: 9302

OMIM: 605983

KEGG: hsa:5518

STRING: 9606.ENSP00000324804

UniGene: Hs.467192