pqe-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pqe-1 antibody; F52C9.8 antibody; Putative RNA exonuclease pqe-1 antibody; PolyQ enhancer protein 1 antibody
Target Names
pqe-1
Uniprot No.
Target Background
Function
Pqe-1 is a putative RNA exonuclease that plays a protective role in neurons against the harmful effects of expanded polyglutamine (poly-Q) disease proteins. While the exact mechanism remains unclear, pqe-1 may either participate in the pathogenic process underlying poly-Q-induced neurodegeneration or act as a genetic modifier influencing the onset and progression of neurodegeneration. Additionally, pqe-1 regulates gene expression in neurons.
Gene References Into Functions
- Mutations in the pqe-1 gene, which encodes a Q/P-rich nuclear protein containing an exonuclease domain, have been found to increase the likelihood of reporter expression in AIZ neurons. PMID: 22870397
Database Links
Protein Families
REXO1/REXO3 family
Subcellular Location
[Isoform a]: Nucleus.
Tissue Specificity
Expressed in the excretory canal, vulval cells, the intestine and in head and tail neurons including ASH, RIC and AIZ neurons.
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