PRDX3 Antibody

1. Studies have shown that tubular PRX3, in combination with conventional predictors, can further improve recovery prediction and may assist in risk stratification for AKI patients with pre-existing CKD. PMID: 28240739
2. Research suggests that decreased PRDX3 levels due to excessive bile acids in trophoblasts play a critical role in the pathogenesis and progression of Intrahepatic cholestasis of pregnancy. PMID: 27958341
3. Mutants have been created to investigate the link between oligomerization and peroxidase activity. An obligate dimer exhibits lower activity compared to the wildtype but still displays peroxidase activity. The 2.4A structure (PDB: 5UCX) reveals a cysteine-stabilized protein interface. PMID: 29438714
4. A recent study identified the protein profiles of the PRDX family in LSCC and demonstrated that down-regulation of PRDX3 in Hep-2 cells induced cell apoptosis and inhibited cell proliferation and migration. PMID: 27966448
5. The interaction between UNG1 and PRDX3 protected UNG1 from reactive oxygen species-mediated degradation and prevented mitochondrial DNA oxidation. PMID: 27480846
6. PRDX3 knockdown resulted in the down-regulation of ATP synthases and decreased cellular ATP levels, contributing to a slower cell growth rate. Additionally, silencing PRDX3 enhanced the invasive properties of HepG2 cells through TIMP-1 down-regulation and increased ECM degradation. PMID: 26983019
7. Prx3 and Trx2 comprise an adaptive system that senses changes in atmospheric oxygen tension and influences cellular injury responses through both detoxification of mitochondrial oxidants and regulation of mitochondrial redox-dependent signaling. PMID: 28045936
8. PRX3 plays a critical role in maintaining mitochondrial homeostasis. PMID: 27037278
9. High PRX3 expression is associated with invasion in lung adenocarcinoma. PMID: 26810067
10. Research has revealed that forkhead box protein 1 (FOXM1)-induced peroxiredoxin 3 (PRDX3) maintains mitochondrial function, and the FOXM1/PRDX3 mitochondrial pathway sustains the survival of colon CSCs. PMID: 26350748
11. Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. PMID: 26797130
12. The species with one disulfide and one hyperoxidized active site was decameric for Prx2 and dimeric for Prx3. Reduction and re-oxidation of the hyperoxidized dimer of Prx3 produced hyperoxidized monomers. PMID: 26614766
13. Data indicates that peroxiredoxin III (PrxIII) is a common direct target of both microRNAs miR-26a-5p and miR-23b-3p. PMID: 24828865
14. Colon cancer stem cells overexpress the mitochondrial gene PRDX3, which is essential for maintaining mitochondrial function and tumorigenesis. This overexpression is regulated by forkhead box protein 1, which also regulates the expression of CD133 in these cells. PMID: 26091938
15. Elevated serum PRDX3 levels are associated with hepatocellular carcinoma. PMID: 25743848
16. Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells. PMID: 25462069
17. Two placental proteins, Prx3 and Prx4, may act as new placental immune targets. PMID: 25323516
18. Serum PRDX3 can be used as a noninvasive biomarker for the diagnosis and/or prognosis of hepatocellular carcinoma. PMID: 24815434
19. High peroxiredoxin 3 protein expression is associated with hepatocellular carcinoma. PMID: 24105047
20. HIF-1alpha is a transcription factor for PRDX3 gene expression in clear cell renal cell carcinoma. PMID: 25093297
21. Data indicates that engineered Prx2 and Prx3 variants with C-terminal residues modulate the extent of hyperoxidation. PMID: 24003226
22. The silencing of PRDX3 triggered cisplatin-mediated apoptosis in ovarian cancer cells, potentially acting through suppression of the NFkappaB signaling pathway. PMID: 23503975
23. Results suggest that PRDX-3 plays a crucial role in regulating oxidation-induced apoptosis in antiandrogen-resistant prostate cancer cells. PMID: 23880827
24. Peroxiredoxin III may be associated with drug resistance in ovarian cancer. PMID: 23564483
25. A fraction of FOXM1 coexists in the cytoplasm with mitochondrial peroxiredoxin 3. PMID: 23018647
26. Drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, and PRDX6 genes in all cancer cell strains, confirming the importance of redox-dependent mechanisms in the development of cisplatin resistance. PMID: 23113308
27. Medulloblastoma tumors exhibit decreased expression of miR-383 but elevated expression of PRDX3. Up-regulation of miR-383 knocks down the expression of PRDX3, inhibits cell proliferation, and promotes apoptosis. PMID: 23157748
28. The effects of PRDX3 in PCa progression may be attributed to the regulatory function of miR-23b, and consequently, miR-23b may be involved in the response of PCa cells to hypoxia stress. PMID: 22710126
29. Single nucleotide polymorphisms in the PRDX3 and RPS19 genes are associated with HPV persistence and cervical precancer/cancer. PMID: 22496757
30. Results indicated that overexpression of PRDX3 was associated with 94.9% of hepatocellular carcinoma and correlated with poor differentiation (P<0.05), suggesting that PRDX3 has a substantial clinical impact on the progression of hepatocarcinoma. PMID: 22344546
31. A report highlights nuclear factor E2-related factor 2-dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer. PMID: 22016591
32. Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. PMID: 21795677
33. The interaction between genetic variations in the PRDX3 gene and dietary fat intake is important for modulating BMI and obesity risk. PMID: 21127481
34. A model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study. PMID: 21385867
35. Paraneoplastic autoimmune reaction against retinal pigment epithelium, with PRDX3 as the putative antigen, may be a cause of acute exudative polymorphous vitelliform maculopathy (AEPVM). PMID: 21220625
36. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. PMID: 20929858
37. Prx3, which resides within mitochondria, was reacted with a selection of hydroperoxides generated by gamma-radiolysis or singlet oxygen, on free amino acids, peptides, and proteins. PMID: 20840079
38. Peroxiredoxin III was significantly up-regulated in cervical cancer tissues. PMID: 20718351
39. Peroxiredoxin III plays a significant role in cell cycle regulation and could be a potential proliferation marker in breast cancer. PMID: 20043069
40. Protein levels of Prx-III, a mitochondrial protein, were significantly decreased in Alzheimer Disease and Down Syndrome. PMID: 11771746
41. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. PMID: 11904290
42. PRDX3 is a c-Myc target gene required to maintain normal mitochondrial function. c-Myc directly activates the expression of a mitochondrial peroxiredoxin that is necessary for Myc-mediated transformation. PMID: 12011429
43. LZK was associated directly with the IKK complex through the kinase domain, and AOP-1 was recruited to the IKK complex through binding to LZK. PMID: 12492477
44. The level of peroxiredoxin 3 is decreased in the frontal cortex of patients with Down syndrome and Pick's disease. PMID: 12650976
45. Peroxiredoxin III is a critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling. PMID: 15280382
46. Findings indicate that RPK118 is a PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking. PMID: 15750338
47. The additive protection by Trx2 and GSH shows that Trx2 and GSH systems are both functionally important at low oxidative stress conditions. PMID: 17548047
48. Finally, the expression level of beta-globin and GATA-1 was dramatically increased in the Prdx III O/E cell line. PMID: 17574212
49. PRDX3 is present throughout the lens and localized to mitochondria in lens epithelial cells. Its induction is an acute response of the lens to increased H2O2. PRDX3 plays an important role in lens H2O2-detoxification, mitochondrial maintenance, and possibly cataract formation. PMID: 17893648
50. FOXO3A mediates Prx III expression, which may play a critical role in the resistance to oxidative stress in cardiac fibroblasts. PMID: 18195003

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HGNC: 9354

OMIM: 604769

KEGG: hsa:10935

STRING: 9606.ENSP00000298510

UniGene: Hs.523302