pro-1 Antibody
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pro-1 antibody; R166.4 antibody; Pre-rRNA-processing protein pro-1 antibody; Proximal proliferation in germline protein 1 antibody
Target Names
pro-1
Uniprot No.
Target Background
Function
The pro-1 Antibody targets a component of the PELP1 complex, which plays a crucial role in the nucleolar stages of 28S rRNA maturation. This complex is also involved in the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. The pro-1 Antibody is essential for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation. Furthermore, it is required in somatic cells to promote normal proliferation and prevent the formation of germline tumors.
Gene References Into Functions
- Research indicates that PRO-1, similar to its yeast ortholog IPI3, significantly influences rRNA processing. Tumors caused by pro-1 mutations can be suppressed by mutations in ncl-1 or lin-35/Rb, both of which elevate pre-rRNA levels. PMID: 16876152
Database Links
Protein Families
WD repeat IPI3/WDR18 family
Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm.
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