[KO Validated] PARP1 Polyclonal Antibody Antibodies
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[KO Validated] PARP1 Polyclonal Antibody

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-227761

Product Name [KO Validated] PARP1 Polyclonal Antibody
Application WB;IHC;IF;IP;ChIP
Application Key Western blotting
Calculated Mw 113kDa
Cellular Location Nucleus,nucleolus
Customer Validation WB (human)
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2).
Isotype IgG
Observed Mw 100kDa, 110kDa, 125kDa
Product Background This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Positive Samples Jurkat,HeLa,RAW264.7,C6,Mouse testis,Mouse brain
Purification Method Affinity purification
Recommended Dilution WB
Reference Product: [KO Validated] PARP1 Polyclonal Antibody
Journal: Oncotarget
Application: WB
IF: 5.168
Species: human
PMID: 29535821
Title: NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma

Product: [KO Validated] PARP1 Polyclonal Antibody
Journal: Close affiliations Biochemical and Biophysical Research Communications
Application: WB
IF:
Species: Human
PMID: 29890135
Title: Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors.
Sequence DQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPL
Species Reactivity Human, Mouse, Rat
Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.