Phospho-Stat3-Y705 pAb Antibodies
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Phospho-Stat3-Y705 pAb

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-227775

Product Name Phospho-Stat3-Y705 pAb
Application WB;IHC;IF
Application Key Western blotting
Calculated Mw 83kDa/87kDa/88kDa
Cellular Location Cytoplasm,Nucleus
Customer Validation IF (Mouse)WB (Human)
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around Y705 of human Stat3 (NP_644805.1).
Isotype IgG
Observed Mw 105kDa
Product Background The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Positive Samples HeLa
Purification Method Affinity purification
Recommended Dilution WB
Reference Product: Phospho-Stat3-Y705 pAb
Journal: Blood
Application: IF
IF: 13.081
Species: Mouse
PMID: 28450306
Title: Osteoblasts support megakaryopoiesis through production of interleukin-9

Product: Phospho-Stat3-Y705 pAb
Journal: Oncotarget
Application: WB
IF: 5.166
Species: Human
PMID: 29190957
Title: MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3
Sequence APYLK
Species Reactivity Human, Mouse, Rat
Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.