Phospho-ERBB4-Y1284 pAb Antibodies
$ $99 In stock

Phospho-ERBB4-Y1284 pAb

Product Name Phospho-ERBB4-Y1284 pAb
Product Type
Host Species Rabbit
Species Reactivity Human, Mouse, Rat
isotype IgG
application WB
Product Background This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Immunogen A synthetic phosphorylated peptide around Y1284 of human ERBB4 (NP_005226.1).
Sequence PEYLS
Customer Validation WB (Mouse) IHC,IF (Mouse)
Recommended Dilution WB
Calculated MW 143kDa/145kDa/146kDa
Observed MW 200kDa
Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key Western blotting
Positive Samples A-431
Cellular Location Cell membrane,Mitochondrion,Nucleus,Single-pass type I membrane protein
Purification Method Affinity purification
RRID AB_2771096