DMPK Polyclonal Antibody Antibodies
$ $99 In stock
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DMPK Polyclonal Antibody

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-230101

Product Name DMPK Polyclonal Antibody
Application WB
Application Key Western blotting
Calculated Mw 59kDa/60kDa/65kDa/67kDa/69kDa/70kDa
Cellular Location Cell membrane,Cytoplasm,Cytoplasmic side,Endoplasmic reticulum membrane,Mitochondrion membrane,Mitochondrion outer membrane,Nucleus outer membrane,Sarcoplasmic reticulum membrane,Single-pass type IV membrane protein,cytosol
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 350-590 of human DMPK (NP_004400.4).
Isotype IgG
Observed Mw 75kDa
Product Background The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Positive Samples A-549
Purification Method Affinity purification
Recommended Dilution WB
Sequence SVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALS
Species Reactivity Human
Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.