MPZ Polyclonal Antibody Antibodies
$ $99 In stock
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MPZ Polyclonal Antibody

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-234643

Product Name MPZ Polyclonal Antibody
Application WB
Application Key Western blotting
Calculated Mw 27kDa/34kDa
Cellular Location Cell membrane,Myelin membrane,Single-pass type I membrane protein
Host Species Rabbit
Immunogen Recombinant protein of human MPZ
Isotype IgG
Observed Mw 27kDa
Product Background This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.
Positive Samples A375,HT-1080,Mouse brain,Mouse heart,Rat brain
Purification Method Affinity purification
Recommended Dilution WB
Sequence Email for sequence
Species Reactivity Human, Mouse, Rat
Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.