CDH1 Polyclonal Antibody
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-240651
| Product Name | CDH1 Polyclonal Antibody |
|---|---|
| Application | WB;IHC |
| Application Key | Western blotting |
| Calculated Mw | 90kDa/97kDa |
| Host Species | Rabbit |
| Immunogen | Recombinant protein of human CDH1. |
| Isotype | IgG |
| Observed Mw | Refer to figures |
| Product Background | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
| Purification Method | Affinity purification |
| Recommended Dilution | WB |
| Sequence | Email for sequence |
| Species Reactivity | Human, Mouse |
| Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |