Recombinant HIV-2 gp-36 397aa
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-224913
Formulation: 0.01M Na2CO3, 0.01M Na3EDTA, 0.014 Mb-mercaptoethanol, 0.05% Tween-20.
|Product Name||Recombinant HIV-2 gp-36 397aa|
|Application||Antibody ELISA, immunogen, WB, etc.|
|Formulation||0.01M Na2CO3, 0.01M Na3EDTA, 0.014 Mb-mercaptoethanol, 0.05% Tween-20.|
|Product Background||HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids. Immunodeficiency develops more slowly with HIV-2. HIV-2 is less infectious in the early stages of the virus than with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C), does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, and is not affected by target membrane glycosphingolipid composition.|
|Product Memo||HIV-2 gp-36 397aa HIV-2 gp36 397aa Recombinant|
|Purity||Greater than 95.0% as determined by HPLC analysis and SDS-PAGE.|
|Stability||Recombinant protein is stable up to 1 year at -80℃|
|Storage||The virus antigen is stable for a month at 4°C. It should be stored at -20°C from the date of shipment. Please avoid repeated freeze thaw cycles.|
|Usage||Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use.|
|Last Modified||Aug 20 2021|