Recombinant HIV Type-O gp41
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-224947
Formulation: 1.5M urea, 25mM Tris-HCl pH 8.0 and 50% Glycerol.
|Product Name||Recombinant HIV Type-O gp41|
|Application||Antibody ELISA, immunogen, WB, etc.|
|Formulation||1.5M urea, 25mM Tris-HCl pH 8.0 and 50% Glycerol.|
|Product Background||Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells.|
|Product Memo||HIV Type-O gp41 HIV Type-O gp41 Recombinant|
|Purity||Greater than 90.0% as determined by SDS-PAGE.|
|Stability||Recombinant protein is stable up to 1 year at -80℃|
|Storage||The virus antigen is stable for a month at 4°C. It should be stored at -20°C from the date of shipment. Please avoid repeated freeze thaw cycles.|
|Usage||Our recombinant proteins are For Research Use Only. This product is not intended or approved for human, diagnostics or veterinary use.|
|Last Modified||Aug 20 2021|