Aspartic acid - 25608-40-6
Aspartic acid
Catalog Number: BT-1217418
CAS Number: 25608-40-6
Molecular Formula: C4H7NO4
Molecular Weight: 133.1 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction
Description
Aspartic acid is a non-essential amino acid that is naturally present in the human body. It is involved in various physiological processes, including protein synthesis, energy production, and neurotransmitter synthesis. Aspartic acid is also found in many food sources, including meat, dairy, and vegetables. In recent years, aspartic acid has gained attention for its potential therapeutic and industrial applications. This paper aims to provide a comprehensive review of aspartic acid, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.
Properties
CAS Number
25608-40-6
Product Name
Aspartic acid
IUPAC Name
(2S)-2-aminobutanedioic acid
Molecular Formula
C4H7NO4
Molecular Weight
133.1 g/mol
InChI
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI Key
CKLJMWTZIZZHCS-REOHCLBHSA-N
SMILES
C(C(C(=O)O)N)C(=O)O
Solubility
5390 mg/L (at 25 °C)
5.36 mg/mL at 25 °C
1 g in 222.2 ml water at 20 °C; 1 g in 149.9 ml water at 30 °C; more sol in salt soln; sol in acids, alkalies
Insoluble in ethanol, ethyl ether, benzene; soluble in dilute HCl, pyridine
In water, 5,360 mg/L at 25 °C
5.39 mg/mL
Solubility in water, g/100ml: 0.45
Slightly soluble in water; Insoluble in ether
Insoluble (in ethanol)
Synonyms
(+-)-Aspartic Acid
(R,S)-Aspartic Acid
Ammonium Aspartate
Aspartate
Aspartate Magnesium Hydrochloride
Aspartate, Ammonium
Aspartate, Calcium
Aspartate, Dipotassium
Aspartate, Disodium
Aspartate, Magnesium
Aspartate, Monopotassium
Aspartate, Monosodium
Aspartate, Potassium
Aspartate, Sodium
Aspartic Acid
Aspartic Acid, Ammonium Salt
Aspartic Acid, Calcium Salt
Aspartic Acid, Dipotassium Salt
Aspartic Acid, Disodium Salt
Aspartic Acid, Hydrobromide
Aspartic Acid, Hydrochloride
Aspartic Acid, Magnesium (1:1) Salt, Hydrochloride, Trihydrate
Aspartic Acid, Magnesium (2:1) Salt
Aspartic Acid, Magnesium-Potassium (2:1:2) Salt
Aspartic Acid, Monopotassium Salt
Aspartic Acid, Monosodium Salt
Aspartic Acid, Potassium Salt
Aspartic Acid, Sodium Salt
Calcium Aspartate
Dipotassium Aspartate
Disodium Aspartate
L Aspartate
L Aspartic Acid
L-Aspartate
L-Aspartic Acid
Magnesiocard
Magnesium Aspartate
Mg-5-Longoral
Monopotassium Aspartate
Monosodium Aspartate
Potassium Aspartate
Sodium Aspartate
Canonical SMILES
C(C(C(=O)O)N)C(=O)O
Isomeric SMILES
C([C@@H](C(=O)O)N)C(=O)O
Method of Synthesis or Extraction
Aspartic acid can be synthesized through various methods, including chemical synthesis, enzymatic synthesis, and microbial fermentation. Chemical synthesis involves the reaction of ammonia with maleic anhydride, followed by hydrolysis to produce aspartic acid. Enzymatic synthesis involves the use of aspartate aminotransferase to catalyze the conversion of oxaloacetate to aspartic acid. Microbial fermentation involves the use of microorganisms, such as Corynebacterium glutamicum, to produce aspartic acid from glucose. Each method has its advantages and disadvantages in terms of efficiency, yield, and environmental and safety considerations.
Chemical Structure and Biological Activity
Aspartic acid is a dicarboxylic acid with the chemical formula C4H7NO4. It has two ionizable groups, a carboxyl group and an amino group, which make it a zwitterion at physiological pH. Aspartic acid is involved in various biological processes, including protein synthesis, energy production, and neurotransmitter synthesis. It is also a precursor to other amino acids, such as asparagine and arginine. Aspartic acid has been shown to have biological activity, including the ability to bind to and activate N-methyl-D-aspartate (NMDA) receptors in the brain, which are involved in learning and memory.
Biological Effects
Aspartic acid has been shown to have various effects on cell function and signal transduction. It has been shown to regulate the activity of enzymes involved in energy production, such as pyruvate dehydrogenase and ATP synthase. Aspartic acid has also been shown to modulate the activity of ion channels, such as NMDA receptors and voltage-gated calcium channels. In terms of potential therapeutic and toxic effects, aspartic acid has been studied for its role in treating neurological disorders, such as Alzheimer's disease and Parkinson's disease. However, high levels of aspartic acid have been associated with neurotoxicity and excitotoxicity.
Applications
Aspartic acid has various applications in medical research, including its role in drug development, clinical trials, and findings, benefits, and potential side effects. Aspartic acid has been studied for its potential therapeutic effects in treating neurological disorders, such as Alzheimer's disease and Parkinson's disease. It has also been studied for its role in improving athletic performance and reducing fatigue. In environmental research, aspartic acid has been studied for its effects on ecosystems, its role in pollution management, and its sustainability and environmental impact. In industrial research, aspartic acid has been used in manufacturing processes, such as the production of biodegradable plastics and detergents. It has also been used to improve product quality and efficiency, such as in the production of food additives and animal feed.
Future Perspectives and Challenges
Despite the potential applications of aspartic acid, there are current limitations in its use and study. One of the main challenges is the toxicity associated with high levels of aspartic acid. Another challenge is the limited understanding of its biological mechanisms and targets. Possible solutions and improvements include the development of safer and more efficient methods of synthesis or extraction, as well as the identification of new biological targets and mechanisms of action. Future trends and prospects in the application of aspartic acid in scientific research include the development of new drugs and therapies for neurological disorders, as well as the use of aspartic acid in sustainable and environmentally friendly manufacturing processes.
Conclusion:
Aspartic acid is a non-essential amino acid that has gained attention for its potential therapeutic and industrial applications. It can be synthesized through various methods, including chemical synthesis, enzymatic synthesis, and microbial fermentation. Aspartic acid has biological activity and has been shown to have various effects on cell function and signal transduction. It has potential therapeutic and toxic effects and has various applications in medical, environmental, and industrial research. Despite current limitations, there are possible solutions and improvements, and future trends and prospects in the application of aspartic acid in scientific research.
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