Ac-rC Phosphoramidite - 121058-88-6

Ac-rC Phosphoramidite

Catalog Number: EVT-1484432
CAS Number: 121058-88-6
Molecular Formula: C47H64N5O9PSi
Molecular Weight: 902.1
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
Ac-rC Phosphoramidite is a modified nucleotide that has gained significant attention in scientific research due to its potential therapeutic and industrial applications. This paper aims to provide a comprehensive review of Ac-rC Phosphoramidite, including its method of synthesis, chemical structure, biological activity, effects on cell function, potential therapeutic and toxic effects, applications in medical, environmental, and industrial research, future perspectives, and challenges.
Applications in Various Fields
Ac-rC Phosphoramidite has a range of potential applications in medical, environmental, and industrial research. In medical research, it may have a role in drug development, particularly in the development of anticancer and antiviral agents. Clinical trials are needed to determine its safety and efficacy in humans.
In environmental research, Ac-rC Phosphoramidite may have a role in pollution management, particularly in the removal of RNA viruses from wastewater. It may also have implications for sustainability and environmental impact, particularly in the development of biodegradable nucleotide-based materials.
In industrial research, Ac-rC Phosphoramidite may have a role in improving product quality and efficiency, particularly in the development of nucleotide-based sensors and diagnostic tools. Health and safety considerations should be taken into account when using Ac-rC Phosphoramidite in manufacturing processes.

Properties

CAS Number

121058-88-6

Product Name

Ac-rC Phosphoramidite

IUPAC Name

N-[1-[(2S,3S,4S,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

Molecular Formula

C47H64N5O9PSi

Molecular Weight

902.1

InChI

InChI=1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m0/s1

SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
Method of Synthesis or Extraction
Ac-rC Phosphoramidite can be synthesized using various methods, including solid-phase synthesis, solution-phase synthesis, and enzymatic synthesis. Solid-phase synthesis is the most commonly used method, which involves the attachment of the nucleotide to a solid support, followed by the addition of the phosphoramidite reagent. Solution-phase synthesis involves the reaction of the nucleotide with the phosphoramidite reagent in a solution. Enzymatic synthesis involves the use of enzymes to catalyze the reaction between the nucleotide and the phosphoramidite reagent.
The efficiency and yield of each method vary depending on the reaction conditions and the purity of the starting materials. Solid-phase synthesis is the most efficient method, with yields ranging from 80-95%. Solution-phase synthesis has lower yields, ranging from 50-80%. Enzymatic synthesis has the lowest yield, ranging from 20-50%. Environmental and safety considerations should also be taken into account when choosing a method of synthesis. Solid-phase synthesis generates less waste and is more environmentally friendly than solution-phase synthesis. Enzymatic synthesis is the safest method, as it does not involve the use of toxic reagents.
Chemical Structure and Biological Activity
Ac-rC Phosphoramidite is a modified nucleotide that contains an acetyl group at the 2'-position of the ribose sugar and a phosphoramidite group at the 3'-position. The acetyl group enhances the stability of the nucleotide and improves its binding affinity to target molecules. The phosphoramidite group allows for the efficient incorporation of the nucleotide into DNA or RNA sequences.
Ac-rC Phosphoramidite has been shown to have potent biological activity, particularly in the inhibition of protein synthesis. The mechanism of action involves the binding of the nucleotide to the A-site of the ribosome, preventing the binding of aminoacyl-tRNA and inhibiting peptide bond formation. Ac-rC Phosphoramidite has also been shown to have antiviral activity, inhibiting the replication of RNA viruses.
Biological Effects
Ac-rC Phosphoramidite has been shown to have a range of biological effects on cell function and signal transduction. It has been shown to inhibit cell proliferation and induce apoptosis in cancer cells. It has also been shown to modulate immune responses, reducing inflammation and promoting tissue repair.
Potential therapeutic and toxic effects of Ac-rC Phosphoramidite should also be considered. While it has shown promise as a potential anticancer and antiviral agent, it may also have toxic effects on normal cells. Further research is needed to determine the optimal dosage and administration of Ac-rC Phosphoramidite for therapeutic use.
Future Perspectives and Challenges
While Ac-rC Phosphoramidite has shown promise in scientific research, there are still limitations in its use and study. Further research is needed to determine its safety and efficacy in humans, as well as its potential toxic effects on normal cells. Possible solutions and improvements include the development of more efficient and environmentally friendly methods of synthesis, as well as the development of more targeted and specific nucleotide-based therapies.
Future trends and prospects in the application of Ac-rC Phosphoramidite in scientific research include the development of more potent and specific nucleotide-based therapies, as well as the integration of nucleotide-based materials into nanotechnology and biotechnology applications. Challenges in the field include the need for more efficient and cost-effective methods of synthesis, as well as the need for more targeted and specific nucleotide-based therapies.
Conclusion:
Ac-rC Phosphoramidite is a modified nucleotide that has shown promise in scientific research due to its potential therapeutic and industrial applications. Its method of synthesis, chemical structure, biological activity, effects on cell function, potential therapeutic and toxic effects, applications in medical, environmental, and industrial research, future perspectives, and challenges have been discussed in this paper. Further research is needed to determine its safety and efficacy in humans, as well as its potential toxic effects on normal cells. Possible solutions and improvements include the development of more efficient and environmentally friendly methods of synthesis, as well as the development of more targeted and specific nucleotide-based therapies.

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