Thymidine 5'-triphosphate sodium salt - 18423-43-3

Thymidine 5'-triphosphate sodium salt

Catalog Number: EVT-1488781
CAS Number: 18423-43-3
Molecular Formula: C10H14N2Na3O14P3
Molecular Weight: 482.17
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
Thymidine 5'-triphosphate sodium salt (TTP) is a nucleotide that plays a crucial role in DNA synthesis and repair. It is a building block of DNA and is essential for cell division and growth. TTP is also involved in various biological processes, including signal transduction, energy metabolism, and gene expression.
Applications in Various Fields
Thymidine 5'-triphosphate sodium salt has various applications in medical, environmental, and industrial research. In medical research, Thymidine 5'-triphosphate sodium salt plays a crucial role in drug development and clinical trials. Thymidine 5'-triphosphate sodium salt analogs have been developed as antiviral and anticancer agents. Thymidine 5'-triphosphate sodium salt deficiency has been linked to various diseases, including mitochondrial disorders and cancer. In environmental research, Thymidine 5'-triphosphate sodium salt is used to study the effects of pollutants on ecosystems and to develop pollution management strategies. Thymidine 5'-triphosphate sodium salt is also used in sustainability and environmental impact studies. In industrial research, Thymidine 5'-triphosphate sodium salt is used in manufacturing processes to improve product quality and efficiency. Health and safety considerations should be taken into account when using Thymidine 5'-triphosphate sodium salt in industrial applications.

Properties

CAS Number

18423-43-3

Product Name

Thymidine 5'-triphosphate sodium salt

IUPAC Name

trisodium;[[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate

Molecular Formula

C10H14N2Na3O14P3

Molecular Weight

482.17

InChI

InChI=1S/C10H17N2O14P3.3Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t6-,7+,8+;;;/m0.../s1

SMILES

CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O.[Na+].[Na+].[Na+]

Synonyms

Thymidine 5’-(Tetrahydrogen Triphosphate) Sodium Salt;
Method of Synthesis or Extraction
Thymidine 5'-triphosphate sodium salt can be synthesized by several methods, including enzymatic synthesis, chemical synthesis, and extraction from natural sources. Enzymatic synthesis involves the use of enzymes such as thymidine kinase and nucleoside diphosphate kinase to convert thymidine monophosphate to Thymidine 5'-triphosphate sodium salt. Chemical synthesis involves the use of chemical reagents to synthesize Thymidine 5'-triphosphate sodium salt from thymidine. Extraction from natural sources involves the isolation of Thymidine 5'-triphosphate sodium salt from biological tissues or microorganisms.
The efficiency and yield of each method vary depending on the conditions and reagents used. Enzymatic synthesis is highly efficient and yields high purity Thymidine 5'-triphosphate sodium salt. Chemical synthesis is less efficient and yields impure Thymidine 5'-triphosphate sodium salt. Extraction from natural sources is also less efficient and yields impure Thymidine 5'-triphosphate sodium salt. Environmental and safety considerations should be taken into account when choosing a method of synthesis or extraction. Enzymatic synthesis is environmentally friendly and safe, while chemical synthesis and extraction from natural sources may involve the use of hazardous chemicals and pose environmental risks.
Chemical Structure and Biological Activity
Thymidine 5'-triphosphate sodium salt is a nucleotide composed of a thymidine base, a ribose sugar, and three phosphate groups. The chemical formula of Thymidine 5'-triphosphate sodium salt is C10H16N2O14P3Na. Thymidine 5'-triphosphate sodium salt is involved in DNA synthesis and repair by providing the energy required for the formation of phosphodiester bonds between nucleotides. Thymidine 5'-triphosphate sodium salt also plays a role in signal transduction by activating protein kinases and regulating gene expression.
Biological Effects
Thymidine 5'-triphosphate sodium salt has various biological effects on cell function and signal transduction. Thymidine 5'-triphosphate sodium salt deficiency can lead to impaired DNA synthesis and repair, resulting in cell death or mutations. Thymidine 5'-triphosphate sodium salt also regulates the activity of protein kinases, which are involved in cell signaling pathways. Thymidine 5'-triphosphate sodium salt has potential therapeutic and toxic effects. Thymidine 5'-triphosphate sodium salt analogs have been developed as antiviral and anticancer agents. However, Thymidine 5'-triphosphate sodium salt toxicity can lead to cell death and tissue damage.
Future Perspectives and Challenges
Current limitations in the use and study of Thymidine 5'-triphosphate sodium salt include the lack of efficient and cost-effective methods of synthesis and extraction, the limited understanding of Thymidine 5'-triphosphate sodium salt's biological functions and mechanisms of action, and the potential toxicity of Thymidine 5'-triphosphate sodium salt analogs. Possible solutions and improvements include the development of new methods of synthesis and extraction, the use of advanced technologies to study Thymidine 5'-triphosphate sodium salt's biological functions, and the development of safer and more effective Thymidine 5'-triphosphate sodium salt analogs. Future trends and prospects in the application of Thymidine 5'-triphosphate sodium salt in scientific research include the development of new drugs and therapies, the study of Thymidine 5'-triphosphate sodium salt's role in aging and disease, and the use of Thymidine 5'-triphosphate sodium salt in biotechnology and nanotechnology.
Conclusion:
Thymidine 5'-triphosphate sodium salt is a nucleotide that plays a crucial role in DNA synthesis and repair, signal transduction, and energy metabolism. Thymidine 5'-triphosphate sodium salt has various applications in medical, environmental, and industrial research. The efficient and safe synthesis and extraction of Thymidine 5'-triphosphate sodium salt, the understanding of Thymidine 5'-triphosphate sodium salt's biological functions and mechanisms of action, and the development of safer and more effective Thymidine 5'-triphosphate sodium salt analogs are essential for the future application of Thymidine 5'-triphosphate sodium salt in scientific research.

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