Thymidine 5'-triphosphate sodium salt - 18423-43-3

Thymidine 5'-triphosphate sodium salt

Catalog Number: EVT-1488781
CAS Number: 18423-43-3
Molecular Formula: C10H14N2Na3O14P3
Molecular Weight: 482.17
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Product Introduction

Description
Thymidine 5’-triphosphate sodium salt solution is used in DNA synthesis reactions such as PCR, DNA sequencing, cDNA synthesis, and molecular cloning techniques .

Synthesis Analysis

Thymidine 5’-diphosphate sodium salt is produced from Thymidine monophosphate by Thymidylate kinase (TMPK), a nucleoside monophosphate kinase, and can be further phosphorylated to its active triphosphate antiviral or antitumor moieties . It is a proximate precursor for DNA synthesis .

Molecular Structure Analysis

Thymidine 5’-diphosphate sodium salt is a nucleoside diphosphate derived from phosphorylation of Thymidine . It can be further phosphorylated to its active triphosphate antiviral or antitumor moieties .

Chemical Reactions Analysis

Thymidine 5’-triphosphate sodium salt is one of the four natural deoxynucleotides, along with deoxyadenosine 5’-triphosphate (dATP), deoxyguanosine 5’-triphosphate (dGTP), and deoxycytosine 5’-triphosphate (dCTP) used for the biosynthesis of deoxyribonucleic acids by DNA polymerases and reverse transcriptases .

Physical And Chemical Properties Analysis

Thymidine 5’-triphosphate sodium salt has an empirical formula of C10H16N2O14P3Na, a CAS Number of 18423-43-3, and a molecular weight of 504.15 . It is stored at a temperature of -20°C .

Properties

CAS Number

18423-43-3

Product Name

Thymidine 5'-triphosphate sodium salt

IUPAC Name

trisodium;[[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate

Molecular Formula

C10H14N2Na3O14P3

Molecular Weight

482.17

InChI

InChI=1S/C10H17N2O14P3.3Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t6-,7+,8+;;;/m0.../s1

SMILES

CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O.[Na+].[Na+].[Na+]

Synonyms

Thymidine 5’-(Tetrahydrogen Triphosphate) Sodium Salt;

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