Recombinant BMPR2 Protein, Human (His Tag)
Others
The human BMPR-II (NP_001195.2) extracellular domain (Met 1-Ile 151) was expressed with a C-terminal polyhistidine tag
The recombinant human BMPR-II consists of 136a.a and has a predicted molecular weight of 15.6 kDa. As a result of glycosylation, the apparent molecular weight of rhBMPR-II is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
Formulation:
The recombinant human BMPR-II consists of 136a.a and has a predicted molecular weight of 15.6 kDa. As a result of glycosylation, the apparent molecular weight of rhBMPR-II is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
Source:
HEK293 Cells
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant BMPR2 Protein, Human (His Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-204453
Molecular Weight: The recombinant human BMPR-II consists of 136a.a and has a predicted molecular weight of 15.6 kDa. As a result of glycosylation, the apparent molecular weight of rhBMPR-II is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
Formulation: Recombinant BMPR2 Protein was lyophilized from sterile PBS, pH 7.41
Source: HEK293 Cells
| Product Name | Recombinant BMPR2 Protein, Human (His Tag) |
|---|---|
| Molecular Weight | The recombinant human BMPR-II consists of 136a.a and has a predicted molecular weight of 15.6 kDa. As a result of glycosylation, the apparent molecular weight of rhBMPR-II is approximately 30-40 kDa in SDS-PAGE under reducing conditions. |
| AA Sequence | Met 1-Ile 151 |
| Bioactivity | Please contact us for detailed information |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Formulation | Recombinant BMPR2 Protein was lyophilized from sterile PBS, pH 7.41 |
| Host Species | Homo sapiens (Human) |
| Description | The human BMPR-II (NP_001195.2) extracellular domain (Met 1-Ile 151) was expressed with a C-terminal polyhistidine tag |
| Product Background | The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signaling leads to exaggerated TGF-beta signaling and altered cellular responses to TGF-beta. In endothelial cells, BMPR2 mutation increases the susceptibility of cells to apoptosis. BMPR2 transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. The intracellular domain of BMPR2 is both necessary and sufficient for receptor complex interaction. It had been identified that BMPR2 plays a key role in cell growth. Its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. The C-terminal tail of BMPR2 provides binding sites for a number of regulatory proteins that may initiate Smad-independent signalling. BMPR2 mutations were predicted to alter the BMP and TGF-b1/SMAD signalling pathways, resulting in proliferation rather than apoptosis of vascular cells, and greatly increase the risk of developing severe pulmonary arterial hypertension. BMPR2 gene result in familial Primary pulmonary hypertension (PPH) transmitted as an autosomal dominant trait, albeit with low penetrance. Heterozygous germline mutations of BMPR2 gene have been identified in patients with familial and sporadic PPH, indicating that BMPR2 may contribute to the maintenance of normal pulmonary vascular structure and function. Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR2 and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. BMPR2 and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH. |
| Product Memo | BMPR-II Protein, Human;BMPR3 Protein, Human;BMR2 Protein, Human;BRK-3 Protein, Human;POVD1 Protein, Human;PPH1 Protein, Human;T-ALK Protein, Human |
| Product Type | Recombinant Protein |
| Source | HEK293 Cells |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Ser 27 |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |
| Last Modified | Jul 26 2021 |