Zinforo
Catalog Number: BT-253015
CAS Number: 400827-46-5
Molecular Formula: C22H21N8O8PS4
Molecular Weight: C22H21N8O8PS4
The product is for non-human research only. Not for therapeutic or veterinary use.
Price:
Product Introduction
Description
Zinforo is a novel antibiotic drug that was approved by the US Food and Drug Administration (FDA) in 2014 for the treatment of acute bacterial skin and skin structure infections (ABSSSI). It is a member of the cephalosporin class of antibiotics and is marketed by AstraZeneca under the brand name Zinforo. This paper aims to provide an overview of the synthesis, chemical structure, biological activity, and potential applications of Zinforo.
Properties
CAS Number
400827-46-5
Product Name
Zinforo
IUPAC Name
(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;acetate
Molecular Formula
C22H21N8O8PS4
Molecular Weight
C22H21N8O8PS4
InChI
InChI=1S/C22H21N8O8PS4.C2H4O2/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10;1-2(3)4/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37);1H3,(H,3,4)/b26-13-;/t14-,19-;/m1./s1
InChI Key
ZCCUWMICIWSJIX-NQJJCJBVSA-N
SMILES
CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)O.CC(=O)[O-]
Solubility
100 mg/ml
Synonyms
ceftaroline fosamil
PPI-0903
PPI0903
TAK-599
TAK599
Teflaro
PPI-0903
PPI0903
TAK-599
TAK599
Teflaro
Canonical SMILES
CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
Isomeric SMILES
CCO/N=C(/C1=NSC(=N1)NP(=O)(O)O)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
Method of Synthesis or Extraction
Zinforo is synthesized using a chemical process that involves the reaction of 7-aminocephalosporanic acid (7-ACA) with a variety of chemical reagents. The most commonly used method for the synthesis of Zinforo involves the reaction of 7-ACA with a thiazolyl-containing side chain, followed by a series of chemical modifications to produce the final product. The efficiency and yield of the synthesis process depend on the quality of the starting materials, the reaction conditions, and the purification methods used. The environmental and safety considerations of the synthesis process are also important, as the use of certain chemical reagents and solvents can have adverse effects on the environment and human health.
Chemical Structure and Biological Activity
Zinforo has a unique chemical structure that consists of a cephalosporin core with a thiazolyl-containing side chain attached to the 7-position. The thiazolyl side chain is responsible for the antibacterial activity of Zinforo, as it interacts with bacterial cell wall synthesis enzymes and inhibits their activity. Zinforo has a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The potency of Zinforo is comparable to other cephalosporin antibiotics, and it has been shown to be effective in the treatment of ABSSSI.
Biological Effects
Zinforo exerts its antibacterial effects by inhibiting the activity of bacterial cell wall synthesis enzymes, which leads to the disruption of bacterial cell wall formation and ultimately bacterial cell death. Zinforo has also been shown to have effects on cell function and signal transduction pathways, although the exact mechanisms of these effects are not well understood. Potential therapeutic and toxic effects of Zinforo are still being studied, but it has been shown to be generally well-tolerated in clinical trials.
Applications
Zinforo has potential applications in medical research, environmental research, and industrial research. In medical research, Zinforo has been used in drug development and clinical trials for the treatment of ABSSSI. Clinical trials have shown that Zinforo is effective and well-tolerated in the treatment of ABSSSI, and it may have potential applications in the treatment of other bacterial infections. In environmental research, Zinforo may have effects on ecosystems and may play a role in pollution management and sustainability. In industrial research, Zinforo may be used in manufacturing processes to improve product quality and efficiency, but health and safety considerations must be taken into account.
Future Perspectives and Challenges
The current limitations in the use and study of Zinforo include the need for further research on its potential therapeutic and toxic effects, as well as its effects on cell function and signal transduction pathways. Possible solutions and improvements include the development of new formulations and delivery methods for Zinforo, as well as the identification of new targets for its antibacterial activity. Future trends and prospects in the application of Zinforo in scientific research include the development of new antibiotics with improved efficacy and safety profiles, as well as the use of Zinforo in combination with other antibiotics to combat antibiotic resistance.
Product FAQ
Q1: How Can I Obtain a Quote for a Product I'm Interested In?
- To receive a quotation, send us an inquiry about the desired product.
- The quote will cover pack size options, pricing, and availability details.
- If applicable, estimated lead times for custom synthesis or sourcing will be provided.
- Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
- New customers generally require full prepayment.
- NET 30 payment terms can be arranged for customers with established credit.
- Contact our customer service to set up a credit account for NET 30 terms.
- We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
- Preferred methods include bank transfers (ACH/wire) and credit cards.
- Request a proforma invoice for bank transfer details.
- For credit card payments, ask sales representatives for a secure payment link.
- Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
- Orders are confirmed upon receiving official order requests.
- Provide full prepayment or submit purchase orders for credit account customers.
- Send purchase orders to sales@thebiotek.com.
- A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
- Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
- You can use your FedEx account; specify this on the purchase order or inform customer service.
- Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
- Reach out to our customer service representatives at sales@thebiotek.com.
- For ongoing order updates or questions, continue using the same email.
- Remember, we're here to help! Feel free to contact us for any queries or further assistance.
Quick Inquiry
Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.
Category
Hot Products
D-ribose-L-cysteine
CAS No.: 232617-15-1
Sterubin
CAS No.: 51857-11-5
Troparil, (+)-
CAS No.: 74163-84-1
![N-Phenyl-d5-N'-[1-(2-phenylethyl)]-4-piperidine](/images/structure/BT-1439938.png)
N-Phenyl-d5-N'-[1-(2-phenylethyl)]-4-piperidine
CAS No.: 1189466-15-6
POE (15) tallow amine
CAS No.: 61791-26-2
5-Cholesten-3beta-25-diol-3-sulfate
CAS No.: 884905-07-1
info@thebiotek.com
256 N Vinedo Ave, Pasadena, California 91107
