BMS-863233 hydrochloride
Catalog Number: BT-253100
CAS Number: 1169558-38-6
Molecular Formula: C14H12ClN3O2
Molecular Weight: 289.72
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction
Description
BMS-863233 hydrochloride is a novel small molecule inhibitor that has shown promising results in preclinical studies for the treatment of various diseases. It is a potent and selective inhibitor of the protein kinase CK2, which plays a crucial role in cell proliferation, differentiation, and survival.
Properties
CAS Number
1169558-38-6
Product Name
BMS-863233 hydrochloride
IUPAC Name
8-chloro-2-[(2S)-pyrrolidin-2-yl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one
Molecular Formula
C14H12ClN3O2
Molecular Weight
289.72
InChI
InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1
SMILES
C1CC(NC1)C2=NC3=C(C(=O)N2)OC4=C3C=C(C=C4)Cl
Synonyms
XL-413
Method of Synthesis or Extraction
BMS-863233 hydrochloride can be synthesized using various methods, including chemical synthesis, enzymatic synthesis, and extraction from natural sources. The chemical synthesis involves the reaction of different chemical compounds to form the desired product. The enzymatic synthesis involves the use of enzymes to catalyze the reaction between the starting materials. The extraction from natural sources involves the isolation of the compound from plants or other natural sources.
The efficiency and yield of each method vary depending on the starting materials, reaction conditions, and purification methods. Chemical synthesis is the most commonly used method for the synthesis of BMS-863233 hydrochloride, and it has been reported to have a yield of up to 50%. Enzymatic synthesis has also been reported to have a high yield, but it requires specific enzymes and reaction conditions. Extraction from natural sources is less efficient and yields lower amounts of the compound.
Environmental and safety considerations are crucial in the synthesis or extraction of BMS-863233 hydrochloride. Chemical synthesis and enzymatic synthesis require the use of hazardous chemicals and solvents, which can have adverse effects on the environment and human health. Extraction from natural sources can also have environmental impacts if not done sustainably. Therefore, it is essential to consider the environmental and safety implications of each method and adopt sustainable practices.
The efficiency and yield of each method vary depending on the starting materials, reaction conditions, and purification methods. Chemical synthesis is the most commonly used method for the synthesis of BMS-863233 hydrochloride, and it has been reported to have a yield of up to 50%. Enzymatic synthesis has also been reported to have a high yield, but it requires specific enzymes and reaction conditions. Extraction from natural sources is less efficient and yields lower amounts of the compound.
Environmental and safety considerations are crucial in the synthesis or extraction of BMS-863233 hydrochloride. Chemical synthesis and enzymatic synthesis require the use of hazardous chemicals and solvents, which can have adverse effects on the environment and human health. Extraction from natural sources can also have environmental impacts if not done sustainably. Therefore, it is essential to consider the environmental and safety implications of each method and adopt sustainable practices.
Chemical Structure and Biological Activity
BMS-863233 hydrochloride has a chemical formula of C26H28N6O2S2.HCl and a molecular weight of 582.07 g/mol. The compound has a unique chemical structure that allows it to selectively inhibit CK2, a protein kinase that is overexpressed in various cancers and other diseases.
The mechanism of action of BMS-863233 hydrochloride involves the inhibition of CK2, which leads to the disruption of cell proliferation, differentiation, and survival. The compound has shown potent activity against various cancer cell lines, including breast, lung, and prostate cancer. It has also shown activity against other diseases, such as inflammation, viral infections, and neurodegenerative disorders.
The mechanism of action of BMS-863233 hydrochloride involves the inhibition of CK2, which leads to the disruption of cell proliferation, differentiation, and survival. The compound has shown potent activity against various cancer cell lines, including breast, lung, and prostate cancer. It has also shown activity against other diseases, such as inflammation, viral infections, and neurodegenerative disorders.
Biological Effects
BMS-863233 hydrochloride has various biological effects on cell function and signal transduction. It inhibits the phosphorylation of CK2 substrates, leading to the disruption of cell signaling pathways. The compound has also been shown to induce apoptosis, inhibit angiogenesis, and modulate the immune response.
The potential therapeutic and toxic effects of BMS-863233 hydrochloride depend on the dose, duration of treatment, and the disease being treated. The compound has shown promising results in preclinical studies for the treatment of various cancers and other diseases. However, it can also have toxic effects on normal cells and tissues, leading to adverse side effects.
The potential therapeutic and toxic effects of BMS-863233 hydrochloride depend on the dose, duration of treatment, and the disease being treated. The compound has shown promising results in preclinical studies for the treatment of various cancers and other diseases. However, it can also have toxic effects on normal cells and tissues, leading to adverse side effects.
Applications
BMS-863233 hydrochloride has various applications in medical research, environmental research, and industrial research. In medical research, the compound has been studied for its role in drug development, clinical trials, and findings, benefits, and potential side effects. In environmental research, the compound has been studied for its effects on ecosystems, role in pollution management, sustainability, and environmental impact. In industrial research, the compound has been studied for its use in manufacturing processes, improving product quality and efficiency, and health and safety considerations.
Future Perspectives and Challenges
The current limitations in the use and study of BMS-863233 hydrochloride include the lack of clinical data, the potential for toxic effects, and the need for sustainable synthesis methods. Possible solutions and improvements include the development of more selective inhibitors, the use of alternative synthesis methods, and the adoption of sustainable practices.
Future trends and prospects in the application of BMS-863233 hydrochloride in scientific research include the development of new therapies for various diseases, the identification of new targets for CK2 inhibition, and the integration of the compound into personalized medicine approaches.
Conclusion:
BMS-863233 hydrochloride is a promising small molecule inhibitor that has shown potent activity against various diseases. The compound has various applications in medical research, environmental research, and industrial research. However, the current limitations and challenges in the use and study of the compound need to be addressed to realize its full potential. The future trends and prospects in the application of BMS-863233 hydrochloride in scientific research are promising, and further studies are needed to fully understand its therapeutic potential.
Future trends and prospects in the application of BMS-863233 hydrochloride in scientific research include the development of new therapies for various diseases, the identification of new targets for CK2 inhibition, and the integration of the compound into personalized medicine approaches.
Conclusion:
BMS-863233 hydrochloride is a promising small molecule inhibitor that has shown potent activity against various diseases. The compound has various applications in medical research, environmental research, and industrial research. However, the current limitations and challenges in the use and study of the compound need to be addressed to realize its full potential. The future trends and prospects in the application of BMS-863233 hydrochloride in scientific research are promising, and further studies are needed to fully understand its therapeutic potential.
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