BGT-226 maleate
Catalog Number: BT-253139
CAS Number: 1245537-68-1
Molecular Formula: C₃₂H₂₉F₃N₆O₆
Molecular Weight: 650.6
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction
Description
BGT-226 maleate is a small molecule inhibitor that targets the phosphatidylinositol 3-kinase (PI3K) pathway. It has been extensively studied for its potential therapeutic applications in various diseases, including cancer, diabetes, and inflammation.
Properties
CAS Number
1245537-68-1
Product Name
BGT-226 maleate
IUPAC Name
(Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one
Molecular Formula
C₃₂H₂₉F₃N₆O₆
Molecular Weight
650.6
InChI
InChI=1S/C28H25F3N6O2.C4H4O4/c1-35-24-16-33-22-6-3-17(18-4-8-25(39-2)34-15-18)13-20(22)26(24)37(27(35)38)19-5-7-23(21(14-19)28(29,30)31)36-11-9-32-10-12-36;5-3(6)1-2-4(7)8/h3-8,13-16,32H,9-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI Key
YUXMAKUNSXIEKN-BTJKTKAUSA-N
SMILES
CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=CC(=O)O)C(=O)O
Synonyms
(Z)-but-2-enedioic acid;8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one
Method of Synthesis or Extraction
BGT-226 maleate can be synthesized using various methods, including chemical synthesis and extraction from natural sources. Chemical synthesis involves the reaction of different chemical compounds to form BGT-226 maleate. The efficiency and yield of this method depend on the purity of the starting materials, reaction conditions, and purification methods. On the other hand, extraction from natural sources involves the isolation of BGT-226 maleate from plants or microorganisms. This method is more environmentally friendly but may have lower yields. Safety considerations for both methods include the handling of toxic chemicals and the use of protective equipment.
Chemical Structure and Biological Activity
BGT-226 maleate has a chemical formula of C₂₃H₂₃N₅O₄S₂ and a molecular weight of 521.6 g/mol. Its chemical structure consists of a pyridine ring, a thiazole ring, and a pyrimidine ring. BGT-226 maleate inhibits the BGT-226 maleate pathway by binding to the ATP-binding site of the BGT-226 maleate enzyme. This leads to the inhibition of downstream signaling pathways, such as the Akt/mTOR pathway, which are involved in cell growth, survival, and metabolism. BGT-226 maleate has been shown to have potent antitumor activity in various cancer cell lines and animal models.
Biological Effects
BGT-226 maleate has been shown to have various biological effects on cell function and signal transduction. It inhibits cell proliferation, induces apoptosis, and suppresses angiogenesis in cancer cells. It also modulates glucose metabolism and insulin signaling in diabetes. However, BGT-226 maleate may have potential toxic effects, such as hepatotoxicity and cardiotoxicity, which need to be further investigated.
Applications
BGT-226 maleate has potential applications in medical research, environmental research, and industrial research. In medical research, BGT-226 maleate has been studied for its role in drug development, clinical trials, and findings. It has shown promising results in preclinical studies and is currently being evaluated in clinical trials for various cancers and diabetes. However, its potential side effects need to be carefully monitored. In environmental research, BGT-226 maleate may have effects on ecosystems and can be used in pollution management. In industrial research, BGT-226 maleate can be used in manufacturing processes to improve product quality and efficiency. Health and safety considerations need to be taken into account when using BGT-226 maleate in industrial settings.
Future Perspectives and Challenges
The current limitations in the use and study of BGT-226 maleate include its potential toxic effects, limited understanding of its mechanism of action, and the need for more clinical trials. Possible solutions and improvements include the development of more specific and less toxic inhibitors, the identification of biomarkers for patient selection, and the use of combination therapies. Future trends and prospects in the application of BGT-226 maleate in scientific research include the development of personalized medicine and the use of BGT-226 maleate in combination with other targeted therapies.
Conclusion:
BGT-226 maleate is a promising small molecule inhibitor that targets the BGT-226 maleate pathway. It has potential applications in various diseases, including cancer and diabetes. However, its potential toxic effects and limited understanding of its mechanism of action need to be further investigated. The development of more specific and less toxic inhibitors and the use of combination therapies may improve its efficacy and safety.
Conclusion:
BGT-226 maleate is a promising small molecule inhibitor that targets the BGT-226 maleate pathway. It has potential applications in various diseases, including cancer and diabetes. However, its potential toxic effects and limited understanding of its mechanism of action need to be further investigated. The development of more specific and less toxic inhibitors and the use of combination therapies may improve its efficacy and safety.
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