Buy Clemizole hydrochloride (BT-253513)

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Clemizole hydrochloride

Catalog Number: BT-253513

CAS Number: 1163-36-6

Molecular Formula: C19H21Cl2N3

Molecular Weight: 362.3 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Clemizole hydrochloride is a synthetic compound that has been used in various fields of research due to its potential therapeutic and environmental applications. It was first synthesized in the 1950s as an antihistamine drug, but recent studies have shown that it has a wide range of biological activities, including antiviral, anticancer, and anti-inflammatory effects. This paper aims to provide an overview of the synthesis, chemical structure, biological activity, and potential applications of clemizole hydrochloride.

Properties

CAS Number

1163-36-6

Product Name

Clemizole hydrochloride

IUPAC Name

1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;hydrochloride

Molecular Formula

C19H21Cl2N3

Molecular Weight

362.3 g/mol

InChI

InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H

InChI Key

DNFMJYXRIMLMBZ-UHFFFAOYSA-N

SMILES

C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.Cl

Solubility

49.5 [ug/mL]

Synonyms

AL 20;Allercur

Canonical SMILES

[H+].C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.[Cl-]

Method of Synthesis or Extraction

Clemizole hydrochloride can be synthesized using various methods, including the reaction of 2-phenyl-1,2-benzisoxazole with 2,2,2-trichloroethyl chloroformate, or the reaction of 2-phenyl-1,2-benzisoxazole with 2,2,2-trichloroethanol in the presence of a base. The yield and efficiency of each method depend on the reaction conditions and the purity of the starting materials. Environmental and safety considerations should also be taken into account during the synthesis process, as some of the reagents used can be hazardous.

Chemical Structure and Biological Activity

Clemizole hydrochloride has a unique chemical structure that consists of a benzisoxazole ring and a phenyl group. It has been shown to have a wide range of biological activities, including inhibition of viral replication, modulation of ion channels, and inhibition of protein-protein interactions. Its mechanism of action involves binding to specific targets in cells, such as the RNA helicase DDX3X, which is essential for viral replication. Clemizole hydrochloride has also been shown to have potent anticancer effects by inducing apoptosis and inhibiting cell proliferation.

Biological Effects

Clemizole hydrochloride has been shown to have various effects on cell function and signal transduction. It can modulate the activity of ion channels, such as the TRPC5 channel, which is involved in calcium signaling and cell migration. It can also inhibit the activity of protein-protein interactions, such as the interaction between DDX3X and HIV-1 Rev protein, which is essential for viral replication. However, clemizole hydrochloride can also have potential toxic effects, such as hepatotoxicity and neurotoxicity, which should be taken into consideration during its use in research.

Applications

Clemizole hydrochloride has potential applications in various fields of research, including medical, environmental, and industrial research. In medical research, it has been shown to have potential therapeutic effects in the treatment of viral infections, cancer, and inflammatory diseases. Clinical trials have also shown promising results in the use of clemizole hydrochloride as an antiviral drug. In environmental research, clemizole hydrochloride can be used to study its effects on ecosystems and its role in pollution management. In industrial research, it can be used in manufacturing processes to improve product quality and efficiency, with health and safety considerations taken into account.

Future Perspectives and Challenges

Despite its potential applications, there are still limitations in the use and study of clemizole hydrochloride. Its toxicity and potential side effects should be further studied to ensure its safety in clinical use. Possible solutions and improvements include the development of more selective and potent analogs of clemizole hydrochloride, as well as the use of nanotechnology to improve its delivery and efficacy. Future trends and prospects in the application of clemizole hydrochloride in scientific research include its use in combination therapy for viral infections and cancer, as well as its potential role in the development of new drugs and therapies.

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