Buy PD 168077 maleate (BT-253971)

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PD 168077 maleate

Catalog Number: BT-253971

CAS Number: 630117-19-0

Molecular Formula: C24H26N4O5

Molecular Weight: 450.5 g/mol

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Product Introduction

Description

PD 168077 maleate is a potent and selective agonist of the dopamine D4 receptor. It has been extensively studied for its potential therapeutic applications in various neurological and psychiatric disorders.

Properties

CAS Number

630117-19-0

Product Name

PD 168077 maleate

IUPAC Name

(Z)-but-2-enedioic acid;N-[[4-(2-cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide

Molecular Formula

C24H26N4O5

Molecular Weight

450.5 g/mol

InChI

InChI=1S/C20H22N4O.C4H4O4/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21;5-3(6)1-2-4(7)8/h2-8,13H,9-12,15H2,1H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI Key

NAEUGRPISCANHO-BTJKTKAUSA-N

SMILES

CC1=CC(=CC=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=CC(=O)O)C(=O)O

Synonyms

N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate

Canonical SMILES

CC1=CC(=CC=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=CC(=O)O)C(=O)O

Isomeric SMILES

CC1=CC(=CC=C1)C(=O)NCN2CCN(CC2)C3=CC=CC=C3C#N.C(=C\C(=O)O)\C(=O)O

Method of Synthesis or Extraction

PD 168077 maleate can be synthesized using various methods, including chemical synthesis, enzymatic synthesis, and microbial synthesis. Chemical synthesis involves the reaction of 4-(4-chlorophenyl)piperidin-4-ol with 4-(2,3-dichlorophenyl)piperazine in the presence of a base. Enzymatic synthesis involves the use of enzymes to catalyze the reaction between 4-(4-chlorophenyl)piperidin-4-ol and 4-(2,3-dichlorophenyl)piperazine. Microbial synthesis involves the use of microorganisms to produce PD 168077 maleate. The efficiency and yield of each method vary, with chemical synthesis being the most efficient and yielding the highest amount of PD 168077 maleate. However, chemical synthesis is associated with environmental and safety considerations, such as the use of toxic chemicals and the generation of hazardous waste.

Chemical Structure and Biological Activity

PD 168077 maleate has a chemical formula of C24H28Cl3N3O2.C4H4O4 and a molecular weight of 603.91 g/mol. Its chemical structure consists of a piperidine ring, a phenyl ring, and a piperazine ring. PD 168077 maleate is a potent and selective agonist of the dopamine D4 receptor, with an affinity of 4.3 nM. It has been shown to stimulate the release of dopamine in the prefrontal cortex and striatum, leading to improved cognitive function and motor activity.

Biological Effects

PD 168077 maleate has been shown to have various biological effects on cell function and signal transduction. It has been shown to increase the activity of the cAMP/PKA signaling pathway, leading to increased dopamine release and improved cognitive function. PD 168077 maleate has also been shown to modulate the activity of the NMDA receptor, leading to improved synaptic plasticity and memory formation. However, PD 168077 maleate also has potential therapeutic and toxic effects, such as the risk of addiction and the potential for neurotoxicity.

Applications

PD 168077 maleate has various applications in medical research, such as its role in drug development and clinical trials. It has been shown to have potential therapeutic applications in various neurological and psychiatric disorders, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and Parkinson's disease. PD 168077 maleate has also been studied for its potential applications in environmental research, such as its effects on ecosystems and its role in pollution management. In industrial research, PD 168077 maleate has been used in manufacturing processes to improve product quality and efficiency, with health and safety considerations being a major concern.

Future Perspectives and Challenges

Despite the potential therapeutic applications of PD 168077 maleate, there are current limitations in its use and study, such as the lack of long-term safety data and the need for further clinical trials. Possible solutions and improvements include the development of more selective and potent agonists of the dopamine D4 receptor and the use of alternative methods of synthesis or extraction that are more environmentally friendly and safer. Future trends and prospects in the application of PD 168077 maleate in scientific research include the development of personalized medicine and the use of PD 168077 maleate in combination with other drugs to improve therapeutic efficacy.
Conclusion:
PD 168077 maleate is a potent and selective agonist of the dopamine D4 receptor that has potential therapeutic applications in various neurological and psychiatric disorders. Its method of synthesis or extraction, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges have been discussed in this paper. Further research is needed to fully understand the potential therapeutic and toxic effects of PD 168077 maleate and to develop safer and more effective drugs for the treatment of neurological and psychiatric disorders.

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