Buy ZD 7114 hydrochloride (BT-254021)

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ZD 7114 hydrochloride

Catalog Number: BT-254021

CAS Number: 129689-28-7

Molecular Formula: C22H31ClN2O6

Molecular Weight: 454.9 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

ZD 7114 hydrochloride is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It has been extensively studied for its potential therapeutic applications in cancer treatment.

Properties

CAS Number

129689-28-7

Product Name

ZD 7114 hydrochloride

IUPAC Name

2-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethoxy]phenoxy]-N-(2-methoxyethyl)acetamide;hydrochloride

Molecular Formula

C22H31ClN2O6

Molecular Weight

454.9 g/mol

InChI

InChI=1S/C22H30N2O6.ClH/c1-27-13-12-24-22(26)17-30-21-9-7-20(8-10-21)28-14-11-23-15-18(25)16-29-19-5-3-2-4-6-19;/h2-10,18,23,25H,11-17H2,1H3,(H,24,26);1H/t18-;/m0./s1

InChI Key

KCAMZVQSGDBGGF-FERBBOLQSA-N

SMILES

COCCNC(=O)COC1=CC=C(C=C1)OCCNCC(COC2=CC=CC=C2)O.Cl

Synonyms

(S)-4-(2-hydroxy-3-phenoxypropylaminoethoxy)-N-(2-methoxyethyl)phenoxyacetamide
ICI D7114
ZD 7114
ZD7114
Zeneca ZD7114

Canonical SMILES

COCCNC(=O)COC1=CC=C(C=C1)OCCNCC(COC2=CC=CC=C2)O.Cl

Isomeric SMILES

COCCNC(=O)COC1=CC=C(C=C1)OCCNC[C@@H](COC2=CC=CC=C2)O.Cl

Method of Synthesis or Extraction

ZD 7114 hydrochloride can be synthesized using various methods, including chemical synthesis and extraction from natural sources. Chemical synthesis involves the reaction of specific chemicals to produce the desired compound. The efficiency and yield of this method depend on the purity of the starting materials, reaction conditions, and the expertise of the chemist. On the other hand, extraction from natural sources involves the isolation of the compound from plants or microorganisms. This method is more environmentally friendly but may have lower yields. Safety considerations for both methods include the handling of toxic chemicals and the use of appropriate protective equipment.

Chemical Structure and Biological Activity

ZD 7114 hydrochloride has a chemical formula of C22H23ClFN5O3 and a molecular weight of 461.9 g/mol. Its mechanism of action involves the inhibition of ZD 7114 hydrochloride tyrosine kinase, which is involved in cell proliferation and survival. ZD 7114 hydrochloride has been shown to have potent anti-tumor activity in preclinical studies, and its bioactivity and potency have been extensively studied.

Biological Effects

ZD 7114 hydrochloride has been shown to have significant effects on cell function and signal transduction. It inhibits the activation of ZD 7114 hydrochloride and downstream signaling pathways, leading to decreased cell proliferation and increased apoptosis. However, it may also have potential toxic effects, including cardiotoxicity and hepatotoxicity. Its potential therapeutic effects in cancer treatment have been extensively studied, and it has shown promising results in clinical trials.

Applications

ZD 7114 hydrochloride has various applications in medical, environmental, and industrial research. In medical research, it has been studied for its role in drug development and its potential therapeutic effects in cancer treatment. Clinical trials have shown promising results, but further research is needed to determine its safety and efficacy. In environmental research, ZD 7114 hydrochloride has been studied for its effects on ecosystems and its role in pollution management. In industrial research, it has been used in manufacturing processes to improve product quality and efficiency, but health and safety considerations must be taken into account.

Future Perspectives and Challenges

Despite its potential therapeutic applications, there are still limitations in the use and study of ZD 7114 hydrochloride. One of the main challenges is its potential toxic effects, which must be carefully evaluated in clinical trials. Possible solutions and improvements include the development of more selective inhibitors and the use of combination therapies. Future trends and prospects in the application of ZD 7114 hydrochloride in scientific research include the development of personalized medicine and the use of biomarkers to predict patient response.
Conclusion:
ZD 7114 hydrochloride is a potent and selective inhibitor of ZD 7114 hydrochloride tyrosine kinase, with potential therapeutic applications in cancer treatment. Its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges have been extensively studied. Further research is needed to determine its safety and efficacy in clinical trials and to develop more selective inhibitors for personalized medicine.

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