PNU 22394 hydrochloride
Catalog Number: BT-254154
CAS Number: 15923-42-9
Molecular Formula: C13H16N2.HCl
Molecular Weight: 236.74 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
PNU 22394 hydrochloride is a chemical compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. It is a selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) and has been shown to have neuroprotective effects.
Properties
CAS Number
15923-42-9
Product Name
PNU 22394 hydrochloride
IUPAC Name
6-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indol-6-ium;chloride
Molecular Formula
C13H16N2.HCl
Molecular Weight
236.74 g/mol
InChI
InChI=1S/C13H16N2.ClH/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15;/h2-5,14H,6-9H2,1H3;1H
InChI Key
SAIGGEUWSYESTR-UHFFFAOYSA-N
SMILES
C[NH+]1C2=C(CCNCC2)C3=CC=CC=C31.[Cl-]
Synonyms
1,2,3,4,5,6-Hexahydro-6-methyl-azepino[4,5-b]indole hydrochloride
Canonical SMILES
C[NH+]1C2=C(CCNCC2)C3=CC=CC=C31.[Cl-]
Method of Synthesis or Extraction
PNU 22394 hydrochloride can be synthesized using various methods, including chemical synthesis and extraction from natural sources. Chemical synthesis involves the reaction of 2-(2-pyridyl) ethylamine with 2-chloro-5-nitropyridine, followed by reduction with sodium borohydride. The yield of this method is approximately 50%, and it requires the use of toxic chemicals, which can have adverse environmental and safety considerations.
Extraction from natural sources involves the isolation of PNU 22394 hydrochloride from plants such as Nicotiana tabacum and Duboisia myoporoides. This method is more environmentally friendly, but the yield is relatively low, making it less efficient than chemical synthesis.
Extraction from natural sources involves the isolation of PNU 22394 hydrochloride from plants such as Nicotiana tabacum and Duboisia myoporoides. This method is more environmentally friendly, but the yield is relatively low, making it less efficient than chemical synthesis.
Chemical Structure and Biological Activity
PNU 22394 hydrochloride has a molecular formula of C12H14ClN3O and a molecular weight of 251.72 g/mol. Its chemical structure consists of a pyridine ring, an ethylamine group, and a nitro group.
PNU 22394 hydrochloride is a selective agonist of the α7 PNU 22394 hydrochloride, which is a ligand-gated ion channel that is widely distributed in the central nervous system. It has been shown to have neuroprotective effects by reducing inflammation and oxidative stress, promoting neuronal survival, and enhancing cognitive function.
PNU 22394 hydrochloride is a selective agonist of the α7 PNU 22394 hydrochloride, which is a ligand-gated ion channel that is widely distributed in the central nervous system. It has been shown to have neuroprotective effects by reducing inflammation and oxidative stress, promoting neuronal survival, and enhancing cognitive function.
Biological Effects
PNU 22394 hydrochloride has been shown to have various biological effects on cell function and signal transduction. It has been demonstrated to enhance synaptic plasticity, improve memory, and reduce anxiety-like behavior in animal models.
In terms of potential therapeutic and toxic effects, PNU 22394 hydrochloride has been investigated for its role in the treatment of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. However, its potential side effects, such as nausea, vomiting, and dizziness, need to be further studied.
In terms of potential therapeutic and toxic effects, PNU 22394 hydrochloride has been investigated for its role in the treatment of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. However, its potential side effects, such as nausea, vomiting, and dizziness, need to be further studied.
Applications
In medical research, PNU 22394 hydrochloride has been used to study the role of α7 PNU 22394 hydrochloride in various neurological disorders. It has also been investigated as a potential drug candidate for the treatment of these disorders. Clinical trials have shown promising results, but further studies are needed to determine its safety and efficacy.
In environmental research, PNU 22394 hydrochloride has been used to study its effects on ecosystems and its role in pollution management. It has been shown to have potential as a biopesticide and as a tool for the remediation of contaminated soils.
In industrial research, PNU 22394 hydrochloride has been used in manufacturing processes to improve product quality and efficiency. Health and safety considerations need to be taken into account when using this compound in industrial settings.
In environmental research, PNU 22394 hydrochloride has been used to study its effects on ecosystems and its role in pollution management. It has been shown to have potential as a biopesticide and as a tool for the remediation of contaminated soils.
In industrial research, PNU 22394 hydrochloride has been used in manufacturing processes to improve product quality and efficiency. Health and safety considerations need to be taken into account when using this compound in industrial settings.
Future Perspectives and Challenges
Current limitations in the use and study of PNU 22394 hydrochloride include its low solubility and poor bioavailability. Possible solutions and improvements include the development of more efficient synthesis methods and the use of drug delivery systems to improve its pharmacokinetic properties.
Future trends and prospects in the application of PNU 22394 hydrochloride in scientific research include the investigation of its potential as a therapeutic agent for various neurological disorders and its role in environmental sustainability. However, challenges such as safety concerns and regulatory issues need to be addressed before its widespread use.
Conclusion:
PNU 22394 hydrochloride is a promising compound with potential therapeutic and environmental applications. Its selective agonist activity on the α7 PNU 22394 hydrochloride has been shown to have neuroprotective effects and has been investigated for its role in the treatment of various neurological disorders. Further studies are needed to determine its safety and efficacy, and solutions need to be developed to overcome its current limitations.
Future trends and prospects in the application of PNU 22394 hydrochloride in scientific research include the investigation of its potential as a therapeutic agent for various neurological disorders and its role in environmental sustainability. However, challenges such as safety concerns and regulatory issues need to be addressed before its widespread use.
Conclusion:
PNU 22394 hydrochloride is a promising compound with potential therapeutic and environmental applications. Its selective agonist activity on the α7 PNU 22394 hydrochloride has been shown to have neuroprotective effects and has been investigated for its role in the treatment of various neurological disorders. Further studies are needed to determine its safety and efficacy, and solutions need to be developed to overcome its current limitations.
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