Buy Dmab-anabaseine dihydrochloride (BT-254159)

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Dmab-anabaseine dihydrochloride

Catalog Number: BT-254159

CAS Number: 154149-38-9

Molecular Formula: C19H23Cl2N3

Molecular Weight: 364.3 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Dmab-anabaseine dihydrochloride is a synthetic compound that belongs to the class of nicotinic acetylcholine receptor agonists. It is a potent and selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) subtype. This compound has been studied for its potential therapeutic applications in various medical conditions, including Alzheimer's disease, schizophrenia, and depression. Additionally, it has been investigated for its potential use in environmental and industrial research.

Properties

CAS Number

154149-38-9

Product Name

Dmab-anabaseine dihydrochloride

IUPAC Name

N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride

Molecular Formula

C19H23Cl2N3

Molecular Weight

364.3 g/mol

InChI

InChI=1S/C19H21N3.2ClH/c1-22(2)18-9-7-15(8-10-18)13-16-5-4-12-21-19(16)17-6-3-11-20-14-17;;/h3,6-11,13-14H,4-5,12H2,1-2H3;2*1H/b16-13+;;

InChI Key

DHCNEWWWKHBASC-YNHPUKFJSA-N

SMILES

CN(C)C1=CC=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3.Cl.Cl

Synonyms

4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride

Canonical SMILES

CN(C)C1=CC=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3.Cl.Cl

Isomeric SMILES

CN(C)C1=CC=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3.Cl.Cl

Method of Synthesis or Extraction

Dmab-anabaseine dihydrochloride can be synthesized using various methods, including chemical synthesis and extraction from natural sources. Chemical synthesis involves the reaction of an appropriate precursor with a suitable reagent to form the desired compound. The efficiency and yield of this method depend on the quality of the starting materials, reaction conditions, and purification methods. Extraction from natural sources involves the isolation of the compound from plants or other organisms that produce it. This method can be more environmentally friendly but may have lower yields and require more extensive purification.

Chemical Structure and Biological Activity

The chemical structure of dmab-anabaseine dihydrochloride consists of a pyridine ring with a dimethylamino group and a quinuclidine ring. It is a potent and selective agonist of the α7 Dmab-anabaseine dihydrochloride subtype, which is involved in various physiological processes, including learning and memory, attention, and inflammation. The compound has been shown to improve cognitive function in animal models of Alzheimer's disease and schizophrenia. Additionally, it has been investigated for its potential use in treating depression and anxiety disorders.

Biological Effects

Dmab-anabaseine dihydrochloride has been shown to modulate various cellular functions and signal transduction pathways. It can enhance synaptic plasticity and improve neuronal survival in animal models of neurodegenerative diseases. However, it may also have potential toxic effects, including neurotoxicity and hepatotoxicity. Further studies are needed to determine the safety and efficacy of this compound in humans.

Applications

In medical research, dmab-anabaseine dihydrochloride has been studied for its potential role in drug development. It has been investigated as a potential treatment for Alzheimer's disease, schizophrenia, and depression. Clinical trials have shown promising results, but further studies are needed to determine its safety and efficacy in humans. In environmental research, the compound has been investigated for its effects on ecosystems and its potential use in pollution management. In industrial research, it has been used in manufacturing processes to improve product quality and efficiency. Health and safety considerations are important in all applications of this compound.

Future Perspectives and Challenges

Current limitations in the use and study of dmab-anabaseine dihydrochloride include its potential toxicity and the need for further studies to determine its safety and efficacy in humans. Possible solutions and improvements include the development of more selective and potent compounds and the use of alternative methods for synthesis and extraction. Future trends and prospects in the application of this compound in scientific research include its potential use in treating other neurological and psychiatric disorders and its role in understanding the mechanisms of nicotinic acetylcholine receptor function.

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