Buy 2-Pyridylethylamine dihydrochloride (BT-254181)

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2-Pyridylethylamine dihydrochloride

Catalog Number: BT-254181

CAS Number: 3343-39-3

Molecular Formula: C7H12Cl2N2

Molecular Weight: 195.09 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

2-Pyridylethylamine dihydrochloride, also known as β-phenylethylamine (PEA), is a naturally occurring monoamine alkaloid that is found in trace amounts in the human brain and other mammalian tissues. It is a biogenic amine that acts as a neurotransmitter and neuromodulator in the central nervous system. PEA is known to have various biological activities, including stimulant, antidepressant, and anxiolytic effects.

Properties

CAS Number

3343-39-3

Product Name

2-Pyridylethylamine dihydrochloride

IUPAC Name

2-pyridin-2-ylethanamine;dihydrochloride

Molecular Formula

C7H12Cl2N2

Molecular Weight

195.09 g/mol

InChI

InChI=1S/C7H10N2.2ClH/c8-5-4-7-3-1-2-6-9-7;;/h1-3,6H,4-5,8H2;2*1H

InChI Key

GPIFKSYYILNJNR-UHFFFAOYSA-N

SMILES

C1=CC=NC(=C1)CCN.Cl.Cl

Synonyms

2-(2-aminoethyl)pyridine
2-(2-aminoethyl)pyridine dihydrochloride
2-(2-aminoethyl)pyridine monohydrochloride
2-(2-pyridyl)ethylamine
2-(beta-aminoethyl)pyridine
2-pyridylethylamine
Lilly 04432
Lilly-04432
LY 04432

Canonical SMILES

C1=CC=NC(=C1)CCN.Cl.Cl

Method of Synthesis or Extraction

2-Pyridylethylamine dihydrochloride can be synthesized by various methods, including the reduction of 2-pyridinecarboxylic acid, the reductive amination of pyridine-2-aldehyde, and the condensation of pyridine-2-carboxaldehyde with ethylamine. The efficiency and yield of each method depend on the reaction conditions and the purity of the starting materials. The environmental and safety considerations of these methods are also important factors to consider. For example, the reduction of 2-pyridinecarboxylic acid requires the use of hazardous reducing agents, such as sodium borohydride or lithium aluminum hydride, which can pose a risk to human health and the environment.

Chemical Structure and Biological Activity

The chemical structure of 2-Pyridylethylamine dihydrochloride consists of a pyridine ring attached to an ethylamine side chain. It is a small molecule that can easily cross the blood-brain barrier and interact with various biological targets. The mechanism of action of PEA is not fully understood, but it is believed to act as a substrate for monoamine oxidase (MAO) and as a releaser of dopamine and norepinephrine. PEA has been shown to have various biological activities, including stimulant, antidepressant, and anxiolytic effects. It has also been reported to have neuroprotective and anti-inflammatory properties.

Biological Effects

2-Pyridylethylamine dihydrochloride has been shown to have various effects on cell function and signal transduction. It has been reported to increase the release of dopamine and norepinephrine, which are neurotransmitters that play a role in mood regulation and cognitive function. PEA has also been shown to modulate the activity of ion channels and receptors, such as the NMDA receptor and the GABA receptor. The potential therapeutic and toxic effects of PEA are still under investigation. Some studies have suggested that PEA may have a role in the treatment of depression, attention deficit hyperactivity disorder (ADHD), and Parkinson's disease. However, the long-term effects of PEA on human health are not fully understood.

Applications

2-Pyridylethylamine dihydrochloride has various applications in medical research, environmental research, and industrial research. In medical research, PEA has been studied for its role in drug development and clinical trials. It has been reported to have potential benefits in the treatment of depression, ADHD, and Parkinson's disease. However, the potential side effects of PEA, such as cardiovascular effects and addiction, need to be further investigated. In environmental research, PEA has been studied for its effects on ecosystems and its role in pollution management. It has been reported to have potential benefits in the treatment of wastewater and the removal of heavy metals from contaminated soil. In industrial research, PEA has been used in manufacturing processes to improve product quality and efficiency. However, health and safety considerations need to be taken into account when using PEA in industrial settings.

Future Perspectives and Challenges

The current limitations in the use and study of 2-Pyridylethylamine dihydrochloride include the lack of understanding of its mechanism of action and the potential side effects on human health. Possible solutions and improvements include the development of more selective and potent PEA analogs and the use of advanced imaging techniques to study its effects on the brain. Future trends and prospects in the application of PEA in scientific research include the development of new therapeutic agents for the treatment of neurological disorders and the use of PEA as a biomarker for the diagnosis of certain diseases.
Conclusion:
2-Pyridylethylamine dihydrochloride is a naturally occurring monoamine alkaloid that has various biological activities and potential applications in medical research, environmental research, and industrial research. The method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges of PEA have been discussed in this paper. Further research is needed to fully understand the mechanism of action and the potential therapeutic and toxic effects of PEA.

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