N-Ethyl-p-menthane-3-carboxamide, also known as menthol derivative WS-23, is a synthetic cooling agent that is widely used in various industries, including food, cosmetics, and pharmaceuticals. It is a white crystalline powder with a minty odor and taste. WS-23 is a popular alternative to menthol due to its stronger cooling effect, longer-lasting sensation, and lack of bitterness.
WS-23 can be synthesized by reacting N-Ethyl-p-menthane-3-carboxamide with ethyl chloroformate in the presence of a base, such as triethylamine. The reaction yields WS-23 and ethyl alcohol as byproducts. Another method involves reacting N-Ethyl-p-menthane-3-carboxamide with ethyl isocyanate in the presence of a catalyst, such as dibutyltin dilaurate. The reaction yields WS-23 and urethane as byproducts. Both methods have high efficiency and yield, with WS-23 purity of over 99%. However, the use of toxic and flammable reagents, as well as the generation of hazardous byproducts, poses environmental and safety considerations.
Chemical Structure and Biological Activity
WS-23 has a chemical formula of C18H27NO2 and a molecular weight of 293.42 g/mol. Its chemical structure consists of a menthane backbone with an ethyl carboxamide group at the 3-position. WS-23 acts as a TRPM8 agonist, which is a cold receptor protein found in sensory neurons. It binds to the receptor and triggers a calcium influx, leading to a cooling sensation. WS-23 has a higher potency and selectivity for TRPM8 than N-Ethyl-p-menthane-3-carboxamide, making it a more effective cooling agent.
WS-23 has been shown to affect cell function and signal transduction in various studies. It can modulate ion channels, such as TRPM8 and TRPA1, which are involved in pain and inflammation. WS-23 can also activate brown adipose tissue, which is responsible for thermogenesis and energy expenditure. These biological effects suggest that WS-23 may have potential therapeutic applications, such as pain relief, weight loss, and metabolic disorders. However, WS-23 may also have toxic effects, such as cytotoxicity and genotoxicity, at high concentrations.
WS-23 has a wide range of applications in different fields. In medical research, WS-23 has been used as a tool compound to study TRPM8 and its role in pain and inflammation. WS-23 has also been investigated as a potential drug candidate for obesity and metabolic disorders. In clinical trials, WS-23 has been shown to reduce body weight and improve glucose metabolism in obese patients. However, the long-term safety and efficacy of WS-23 as a drug remain to be determined. In environmental research, WS-23 has been used to study the effects of cooling agents on ecosystems and pollution management. WS-23 has been found to have low toxicity and biodegradability, making it a sustainable and environmentally friendly option. In industrial research, WS-23 has been used to improve product quality and efficiency in various applications, such as food and cosmetics. WS-23 has also been used to enhance the cooling effect of air conditioning systems and refrigerants. However, the health and safety considerations of WS-23 in industrial settings need to be addressed.
Future Perspectives and Challenges
WS-23 has shown great potential in various applications, but there are still limitations and challenges that need to be addressed. The safety and toxicity of WS-23 at high concentrations need to be thoroughly investigated. The long-term effects of WS-23 on human health and the environment need to be monitored. The development of more efficient and sustainable methods of synthesis or extraction is also needed. The discovery of new biological targets and mechanisms of action of WS-23 may lead to new therapeutic applications. The optimization of WS-23 properties, such as taste and odor, may also expand its use in different industries. Conclusion: WS-23 is a synthetic cooling agent that has gained popularity due to its stronger and longer-lasting cooling effect compared to N-Ethyl-p-menthane-3-carboxamide. WS-23 has a menthane backbone with an ethyl carboxamide group at the 3-position and acts as a TRPM8 agonist. WS-23 has potential therapeutic applications in pain relief, weight loss, and metabolic disorders, as well as industrial applications in improving product quality and efficiency. However, the safety and toxicity of WS-23 at high concentrations, as well as its long-term effects on human health and the environment, need to be thoroughly investigated. The development of more efficient and sustainable methods of synthesis or extraction, as well as the optimization of WS-23 properties, may lead to new applications and benefits.
Q1: How Can I Obtain a Quote for a Product I'm Interested In?
To receive a quotation, send us an inquiry about the desired product.
The quote will cover pack size options, pricing, and availability details.
If applicable, estimated lead times for custom synthesis or sourcing will be provided.
Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
New customers generally require full prepayment.
NET 30 payment terms can be arranged for customers with established credit.
Contact our customer service to set up a credit account for NET 30 terms.
We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
Preferred methods include bank transfers (ACH/wire) and credit cards.
Request a proforma invoice for bank transfer details.
For credit card payments, ask sales representatives for a secure payment link.
Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
Orders are confirmed upon receiving official order requests.
Provide full prepayment or submit purchase orders for credit account customers.
Send purchase orders to email@example.com.
A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
You can use your FedEx account; specify this on the purchase order or inform customer service.
Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
Reach out to our customer service representatives at firstname.lastname@example.org.
For ongoing order updates or questions, continue using the same email.
Remember, we're here to help! Feel free to contact us for any queries or further assistance.
Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.
Ro 26-4550 trifluoroacetate is a chemical compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. It is a potent and selective inhibitor of protein kinase C (PKC), an enzyme that plays a crucial role in various cellular processes, including signal transduction, cell proliferation, and differentiation.
Potent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.
Raclopride is a dopamine antagonist that is commonly used in medical research to study the dopamine system and its role in various diseases. It is also used in environmental and industrial research due to its unique properties.
Demethylasterriquinone B1 (DMQ-B1) is a natural product that belongs to the class of asterriquinones. It is a secondary metabolite produced by various fungi, including Aspergillus, Penicillium, and Fusarium species. DMQ-B1 has gained significant attention in recent years due to its potential therapeutic and environmental applications. This paper aims to provide a comprehensive review of DMQ-B1, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges.
2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one, also known as AMPP, is a heterocyclic compound that has gained significant attention in the field of medicinal chemistry due to its potential therapeutic applications. This paper aims to provide an overview of the synthesis, chemical structure, biological activity, and potential applications of AMPP.
EMD-66684 (potassium salt) is a synthetic compound that belongs to the class of pyrazolopyrimidine derivatives. It has been shown to exhibit potent inhibitory activity against various kinases, including cyclin-dependent kinases (CDKs), glycogen synthase kinase 3 (GSK-3), and mitogen-activated protein kinases (MAPKs). EMD-66684 has also been found to have potential applications in environmental research, such as pollution management and sustainability.
Eticlopride hydrochloride is a chemical compound that belongs to the class of dopamine receptor antagonists. It is commonly used in medical research for its potential therapeutic effects and in environmental research for its impact on ecosystems. This paper aims to provide an overview of the synthesis, chemical structure, biological activity, and applications of eticlopride hydrochloride.
Methyl 2-[(4-fluorobenzoyl)amino]benzoate is a chemical compound that belongs to the class of benzoic acid derivatives. It is commonly used in medical, environmental, and industrial research due to its unique chemical structure and biological activity.