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Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
TC 1698 dihydrochloride is a chemical compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. It is a selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) and has been shown to have neuroprotective and anti-inflammatory effects.
SSR 69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively). It inhibits human neutrophil elastase ex vivo in mouse bronchoalveolar lavage (BAL) fluid (ED50 = 10.5 mg/kg, p.o.). In vivo, SSR 69071 (2.8 mg/kg, p.o.) reduces acute lung hemorrhage induced by human neutrophil elastase in mice. It reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively). SSR 69071 also reduces cardiac infarct size when administered prior to ischemia or reperfusion in a rabbit model of ischemia-reperfusion injury. High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM� for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.
3-Dibenzofuran-3-yl-2-(phosphonomethylamino)propionic acid, also known as Fospropofol, is a water-soluble prodrug of propofol, which is a widely used intravenous anesthetic agent. Fospropofol is metabolized to propofol in the body, which produces sedation and hypnosis. Fospropofol has been approved by the US Food and Drug Administration (FDA) for use in monitored anesthesia care (MAC) sedation in adults undergoing diagnostic or therapeutic procedures.
Tfb-tboa is a chemical compound that has gained significant attention in scientific research due to its potential therapeutic and environmental applications. This paper aims to provide an overview of the synthesis and extraction methods, chemical structure, biological activity, and potential applications of Tfb-tboa. Additionally, the paper will discuss the current limitations and future prospects of Tfb-tboa in scientific research.
5-Nitroso-8-hydroxyquinoline (NOQ) is a chemical compound that has gained significant attention in recent years due to its potential therapeutic and environmental applications. It is a derivative of 8-hydroxyquinoline, which is a well-known chelating agent used in various industrial and medical applications. NOQ has been found to exhibit potent biological activity, making it a promising candidate for drug development and environmental remediation.
7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one is a heterocyclic compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. This paper aims to provide an overview of the synthesis, chemical structure, biological activity, and potential applications of this compound.
PB 28 dihydrochloride is a synthetic compound that belongs to the class of phenylpiperazine derivatives. It is a potent and selective agonist of the sigma-1 receptor, which is a transmembrane protein involved in various cellular processes. PB 28 dihydrochloride has gained significant attention in recent years due to its potential therapeutic applications in various fields, including medical, environmental, and industrial research.