ZM 323881 hydrochloride - 193000-39-4
ZM 323881 hydrochloride
Catalog Number: BT-254315
CAS Number: 193000-39-4
Molecular Formula: C22H19ClFN3O2
Molecular Weight: 411.9 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction
Description
ZM 323881 hydrochloride is a small molecule inhibitor that has been extensively studied for its potential therapeutic applications. It is a potent and selective inhibitor of the protein kinase CK2, which is involved in various cellular processes such as cell proliferation, differentiation, and apoptosis.
Properties
CAS Number
193000-39-4
Product Name
ZM 323881 hydrochloride
IUPAC Name
4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol;hydrochloride
Molecular Formula
C22H19ClFN3O2
Molecular Weight
411.9 g/mol
InChI
InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H
InChI Key
AVRHWGLIYGJSOD-UHFFFAOYSA-N
SMILES
CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F.Cl
Synonyms
4-fluoro-2-methyl-5-[(7-phenylmethoxyquinazolin-4-yl)amino]phenol;hydrochloride
Canonical SMILES
CC1=CC(=C(C=C1O)NC2=NC=NC3=C2C=CC(=C3)OCC4=CC=CC=C4)F.Cl
Method of Synthesis or Extraction
ZM 323881 hydrochloride can be synthesized using various methods, including chemical synthesis and extraction from natural sources. Chemical synthesis involves the use of organic chemistry techniques to create the compound. The efficiency and yield of this method depend on the expertise of the chemist and the quality of the starting materials. On the other hand, extraction from natural sources involves isolating the compound from plants or other organisms. This method is more environmentally friendly but may have lower yields. Safety considerations for both methods include the use of hazardous chemicals and the need for proper disposal of waste materials.
Chemical Structure and Biological Activity
The chemical structure of ZM 323881 hydrochloride consists of a pyrazolo[1,5-a]pyrimidine core with a 4-methylpiperazine group attached to the N1 position. The compound has a molecular weight of 383.9 g/mol. ZM 323881 hydrochloride is a potent and selective inhibitor of CK2, with an IC50 value of 2 nM. CK2 is a serine/threonine kinase that is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. Inhibition of CK2 by ZM 323881 hydrochloride has been shown to induce apoptosis in cancer cells and inhibit tumor growth in animal models.
Biological Effects
ZM 323881 hydrochloride has been shown to have various biological effects on cell function and signal transduction. Inhibition of CK2 by ZM 323881 hydrochloride has been shown to induce apoptosis in cancer cells and inhibit tumor growth in animal models. Additionally, ZM 323881 hydrochloride has been shown to inhibit the Wnt/β-catenin signaling pathway, which is involved in cell proliferation and differentiation. Potential therapeutic effects of ZM 323881 hydrochloride include its use in cancer treatment and as an anti-inflammatory agent. However, the compound may also have potential toxic effects, as inhibition of CK2 may affect normal cellular processes.
Applications
ZM 323881 hydrochloride has various applications in medical, environmental, and industrial research. In medical research, ZM 323881 hydrochloride has been studied for its potential role in drug development, particularly in cancer treatment. Clinical trials have shown promising results in the treatment of various types of cancer, including breast, prostate, and lung cancer. However, further studies are needed to determine the optimal dosage and potential side effects of the compound. In environmental research, ZM 323881 hydrochloride has been studied for its effects on ecosystems and its potential role in pollution management. The compound has been shown to have low toxicity to aquatic organisms, making it a potential candidate for use in pollution management. In industrial research, ZM 323881 hydrochloride has been studied for its use in manufacturing processes and improving product quality and efficiency. Health and safety considerations include the need for proper handling and disposal of the compound.
Future Perspectives and Challenges
Current limitations in the use and study of ZM 323881 hydrochloride include the need for further studies to determine the optimal dosage and potential side effects of the compound. Additionally, the compound may have potential toxic effects, as inhibition of CK2 may affect normal cellular processes. Possible solutions and improvements include the development of more selective inhibitors of CK2 and the use of combination therapies to minimize potential side effects. Future trends and prospects in the application of ZM 323881 hydrochloride in scientific research include its potential use in personalized medicine and the development of new cancer treatments.
Conclusion:
ZM 323881 hydrochloride is a potent and selective inhibitor of CK2 that has various potential applications in medical, environmental, and industrial research. The compound has been extensively studied for its potential therapeutic applications, particularly in cancer treatment. However, further studies are needed to determine the optimal dosage and potential side effects of the compound. The development of more selective inhibitors of CK2 and the use of combination therapies may help minimize potential side effects and improve the efficacy of the compound.
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