(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses . At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% .in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists .
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, also known as Compound 401, is a chemical compound that has been extensively studied for its potential therapeutic and industrial applications. This paper aims to provide a comprehensive review of the synthesis, chemical structure, biological activity, and potential applications of this compound.
7-Propyl spirolactone is a chemical compound that belongs to the class of spirolactones. It is a cyclic organic compound that contains a spirolactone ring and a propyl group attached to it. This compound has gained significant attention in the scientific community due to its potential therapeutic and environmental applications.
Platelet activating factor (PAF) is a potent lipid mediator that plays a crucial role in various physiological and pathological processes. It is a phospholipid-derived molecule that is synthesized by various cells, including platelets, leukocytes, endothelial cells, and smooth muscle cells. PAF is involved in a wide range of biological activities, including inflammation, immune response, cell proliferation, and apoptosis. We will also highlight the future perspectives and challenges in the use and study of PAF.
N-Ethyl-p-menthane-3-carboxamide, also known as menthol derivative WS-23, is a synthetic cooling agent that is widely used in various industries, including food, cosmetics, and pharmaceuticals. It is a white crystalline powder with a minty odor and taste. WS-23 is a popular alternative to menthol due to its stronger cooling effect, longer-lasting sensation, and lack of bitterness.
3-Methyl-3-propylcyclopropane-1,1,2,2-tetracarbonitrile is a chemical compound that belongs to the family of cyclopropane derivatives. It is commonly used in medical, environmental, and industrial research due to its unique chemical structure and biological activity.
Selective mGlu1 antagonist (Ki = 13 nM). Inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM). Displays antinociceptive and analgesic effects in vitro; exhibits no significant sedative effect on locomotor activity.
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea, also known as BAY 43-9006 or Sorafenib, is a small molecule drug that has been approved by the US Food and Drug Administration (FDA) for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma. It is a multi-kinase inhibitor that targets several signaling pathways involved in tumor growth and angiogenesis.
Edelfosine is a synthetic alkyl-lysophospholipid that has been extensively studied for its potential therapeutic applications in various diseases, including cancer, parasitic infections, and autoimmune disorders. It was first synthesized in the 1980s and has since been the subject of numerous studies investigating its chemical structure, biological activity, and potential clinical applications.