Buy Esomeprazole magnesium trihydrate (BT-254370)

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Esomeprazole magnesium trihydrate

Catalog Number: BT-254370

CAS Number: 217087-09-7

Molecular Formula: C34H42MgN6O9S2

Molecular Weight: 767.2 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Esomeprazole magnesium trihydrate is a proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and other acid-related disorders. It is a white crystalline powder that is soluble in water and has a molecular weight of 767.17 g/mol. Esomeprazole magnesium trihydrate is the S-enantiomer of omeprazole and is more potent than omeprazole due to its higher binding affinity to the proton pump.

Properties

CAS Number

217087-09-7

Product Name

Esomeprazole magnesium trihydrate

IUPAC Name

magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;trihydrate

Molecular Formula

C34H42MgN6O9S2

Molecular Weight

767.2 g/mol

InChI

InChI=1S/2C17H18N3O3S.Mg.3H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;;;/h2*5-8H,9H2,1-4H3;;3*1H2/q2*-1;+2;;;

InChI Key

VEVZQDGATGBLIC-OXLUMUBXSA-N

SMILES

CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.O.O.O.[Mg+2]

Synonyms

Esomeprazole
Esomeprazole Magnesium
Esomeprazole Potassium
Esomeprazole Sodium
Esomeprazole Strontium
Esomeprazole Strontium Anhydrous
Nexium
Strontium, Esomeprazole

Canonical SMILES

CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.O.O.O.[Mg+2]

Isomeric SMILES

CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.O.O.O.[Mg+2]

Method of Synthesis or Extraction

Esomeprazole magnesium trihydrate is synthesized by the condensation of 5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole with magnesium oxide. The reaction is carried out in the presence of a solvent such as methanol or ethanol. The yield of esomeprazole magnesium trihydrate is typically around 70-80%. The synthesis process is efficient and cost-effective, but it requires careful handling of the reagents due to their toxicity. The environmental impact of the synthesis process is minimal.

Chemical Structure and Biological Activity

Esomeprazole magnesium trihydrate is a substituted benzimidazole that inhibits the H+/K+-ATPase enzyme in the gastric parietal cells, thereby reducing the production of gastric acid. The drug has a high binding affinity to the proton pump and is rapidly absorbed in the small intestine. Esomeprazole magnesium trihydrate has a bioavailability of 64% and a half-life of 1-2 hours. The drug is metabolized in the liver and excreted in the urine.

Biological Effects

Esomeprazole magnesium trihydrate has been shown to have a significant impact on cell function and signal transduction. The drug inhibits the secretion of gastric acid, which can lead to a reduction in the symptoms of GERD and peptic ulcer disease. Esomeprazole magnesium trihydrate has also been shown to have potential therapeutic effects in the treatment of Helicobacter pylori infection, Zollinger-Ellison syndrome, and non-steroidal anti-inflammatory drug-induced ulcers. However, the drug may also have potential toxic effects, such as an increased risk of bone fractures and Clostridium difficile infection.

Applications

In medical research, esomeprazole magnesium trihydrate has played a significant role in drug development and clinical trials. The drug has been used in the development of new Esomeprazole magnesium trihydrates and in the treatment of acid-related disorders. Clinical trials have shown that esomeprazole magnesium trihydrate is effective in reducing the symptoms of GERD and peptic ulcer disease. However, the drug may also have potential side effects, such as headache, nausea, and diarrhea.
In environmental research, esomeprazole magnesium trihydrate has been studied for its effects on ecosystems and its role in pollution management. The drug has been found to have a minimal impact on the environment, and its use in pollution management is limited.
In industrial research, esomeprazole magnesium trihydrate has been used in manufacturing processes to improve product quality and efficiency. The drug has also been studied for its health and safety considerations in the workplace.

Future Perspectives and Challenges

The current limitations in the use and study of esomeprazole magnesium trihydrate include its potential side effects and the development of drug resistance. Possible solutions and improvements include the development of new Esomeprazole magnesium trihydrates with fewer side effects and the use of combination therapies to reduce the risk of drug resistance. Future trends and prospects in the application of esomeprazole magnesium trihydrate in scientific research include the development of personalized medicine and the use of biomarkers to predict drug response.

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