4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide - 10179-57-4
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
Catalog Number: BT-254704
CAS Number: 10179-57-4
Molecular Formula: C21H19N3O2S
Molecular Weight: 377.5 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, also known as DPPS, is a chemical compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. This paper aims to provide a comprehensive overview of DPPS, including its method of synthesis, chemical structure, biological activity, potential therapeutic and toxic effects, applications in medical, environmental, and industrial research, future perspectives, and challenges.
Properties
CAS Number
10179-57-4
Product Name
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
IUPAC Name
4-(3,5-diphenyl-3,4-dihydropyrazol-2-yl)benzenesulfonamide
Molecular Formula
C21H19N3O2S
Molecular Weight
377.5 g/mol
InChI
InChI=1S/C21H19N3O2S/c22-27(25,26)19-13-11-18(12-14-19)24-21(17-9-5-2-6-10-17)15-20(23-24)16-7-3-1-4-8-16/h1-14,21H,15H2,(H2,22,25,26)
InChI Key
OPPCVEVPKHRJNY-UHFFFAOYSA-N
SMILES
C1C(N(N=C1C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4
Synonyms
4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide
Canonical SMILES
C1C(N(N=C1C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4
Method of Synthesis or Extraction
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide can be synthesized using various methods, including the reaction of 4-(4,5-dihydro-3-phenyl-1H-pyrazol-1-yl)benzenesulfonamide with phenylhydrazine in the presence of a catalyst. Another method involves the reaction of 4-(4,5-dihydro-3-phenyl-1H-pyrazol-1-yl)benzenesulfonamide with nitrous acid and phenylhydrazine. The efficiency and yield of each method depend on the reaction conditions, such as temperature, pressure, and reaction time. However, the synthesis of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide requires the use of toxic and hazardous chemicals, which poses environmental and safety considerations.
Chemical Structure and Biological Activity
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide has a molecular formula of C24H21N3O2S and a molecular weight of 427.51 g/mol. The chemical structure of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide consists of a pyrazole ring, a benzene ring, and a sulfonamide group. 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide has been shown to exhibit potent inhibitory activity against carbonic anhydrase IX, which is overexpressed in various types of cancer cells. 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide also exhibits anti-inflammatory and analgesic effects by inhibiting the activity of cyclooxygenase-2.
Biological Effects
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide has been shown to affect cell function and signal transduction by inhibiting the activity of carbonic anhydrase IX and cyclooxygenase-2. 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide has potential therapeutic effects in the treatment of cancer, inflammation, and pain. However, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide may also exhibit toxic effects, such as hepatotoxicity and nephrotoxicity, which require further investigation.
Applications
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide has potential applications in medical, environmental, and industrial research. In medical research, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide may play a role in drug development, as a potential therapeutic agent for cancer, inflammation, and pain. Clinical trials and findings are needed to determine the safety and efficacy of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide in humans. In environmental research, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide may have effects on ecosystems and may play a role in pollution management. In industrial research, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide may be used in manufacturing processes to improve product quality and efficiency. Health and safety considerations are essential when using 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide in industrial applications.
Future Perspectives and Challenges
The use and study of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide face several limitations, such as the lack of clinical data and the potential toxic effects. Possible solutions and improvements include the development of safer and more efficient synthesis methods and the investigation of the mechanisms of action and potential therapeutic effects of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide. Future trends and prospects in the application of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide in scientific research include the development of novel drugs and the exploration of its potential environmental and industrial applications.
Conclusion:
In conclusion, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide is a chemical compound with potential therapeutic and environmental applications. The synthesis of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide requires the use of toxic and hazardous chemicals, which poses environmental and safety considerations. 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide exhibits potent inhibitory activity against carbonic anhydrase IX and cyclooxygenase-2, which may have therapeutic effects in the treatment of cancer, inflammation, and pain. However, 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide may also exhibit toxic effects, which require further investigation. The use and study of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide face several limitations, and possible solutions and improvements include the development of safer and more efficient synthesis methods and the investigation of its mechanisms of action and potential therapeutic effects.
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