AC-262536
Catalog Number: BT-256978
CAS Number: 870888-46-3
Molecular Formula: C18H18N2O
Molecular Weight: 278.36
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
AC-262536 is a synthetic androgen receptor modulator (SARM) that has gained attention in recent years due to its potential therapeutic applications. It was first developed by Acadia Pharmaceuticals in 2007 and has since been studied for its effects on muscle growth, bone density, and cognitive function. This paper aims to provide a comprehensive review of AC-262536, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.
Properties
CAS Number
870888-46-3
Product Name
AC-262536
IUPAC Name
4-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile
Molecular Formula
C18H18N2O
Molecular Weight
278.36
InChI
InChI=1S/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15?
InChI Key
ATKWLNSCJYLXPF-YIONKMFJSA-N
SMILES
C1CC2CC(CC1N2C3=CC=C(C4=CC=CC=C43)C#N)O
Solubility
Soluble in DMSO
Synonyms
AC-262536; AC 262536; AC262536
Method of Synthesis or Extraction
AC-262536 is synthesized through a multi-step process that involves the reaction of various chemical compounds. The most commonly used method of synthesis involves the reaction of 4-chloro-3-nitrobenzoic acid with 2-amino-2-methyl-1-propanol to form the intermediate compound, which is then reacted with 4-(trifluoromethyl)phenylboronic acid to produce AC-262536. The yield of this method is reported to be around 50%, with a purity of over 99%. However, this method requires the use of toxic and hazardous chemicals, which can pose environmental and safety concerns.
Chemical Structure and Biological Activity
AC-262536 has a chemical formula of C18H18F3N3O3 and a molecular weight of 393.35 g/mol. Its chemical structure consists of a benzene ring, a nitro group, and a trifluoromethyl group. AC-262536 is a selective androgen receptor modulator (AC-262536) that binds to androgen receptors in the body, leading to an increase in muscle mass and bone density. It has also been shown to improve cognitive function and memory in animal studies.
Biological Effects
AC-262536 has been shown to have a variety of biological effects on cell function and signal transduction. It activates androgen receptors in muscle and bone cells, leading to an increase in protein synthesis and muscle growth. It also promotes bone mineralization and increases bone density. In addition, AC-262536 has been shown to improve cognitive function and memory in animal studies. However, its potential therapeutic and toxic effects in humans are still being studied.
Applications
AC-262536 has potential applications in medical research, environmental research, and industrial research. In medical research, it is being studied for its role in drug development, particularly in the treatment of muscle wasting and osteoporosis. Clinical trials are ongoing to determine its safety and efficacy in humans. In environmental research, AC-262536 is being studied for its effects on ecosystems and its role in pollution management. Its use in manufacturing processes can improve product quality and efficiency, but health and safety considerations must be taken into account.
Future Perspectives and Challenges
The use and study of AC-262536 face several limitations, including its potential toxicity and lack of long-term safety data. Possible solutions and improvements include the development of safer and more efficient synthesis methods and the conduct of more extensive clinical trials to determine its safety and efficacy in humans. Future trends and prospects in the application of AC-262536 in scientific research include its potential use in the treatment of various diseases and its role in improving human health and well-being.
Conclusion
AC-262536 is a synthetic androgen receptor modulator that has potential therapeutic applications in the treatment of muscle wasting, osteoporosis, and cognitive decline. Its chemical structure and biological activity have been extensively studied, and its potential applications in medical, environmental, and industrial research are being explored. However, its potential toxicity and lack of long-term safety data pose challenges to its use and study. Further research is needed to determine its safety and efficacy in humans and to develop safer and more efficient synthesis methods.
Conclusion
AC-262536 is a synthetic androgen receptor modulator that has potential therapeutic applications in the treatment of muscle wasting, osteoporosis, and cognitive decline. Its chemical structure and biological activity have been extensively studied, and its potential applications in medical, environmental, and industrial research are being explored. However, its potential toxicity and lack of long-term safety data pose challenges to its use and study. Further research is needed to determine its safety and efficacy in humans and to develop safer and more efficient synthesis methods.
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