The first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2) AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid, also known as DPBA, is a pyrrole derivative that has gained significant attention in the scientific community due to its potential therapeutic and industrial applications. DPBA is a versatile compound that exhibits a wide range of biological activities, making it a promising candidate for drug development, environmental research, and industrial applications.
Tilarginine hydrochloride is a synthetic inhibitor of nitric oxide synthase (NOS), an enzyme that catalyzes the production of nitric oxide (NO) from L-arginine. It has been studied for its potential therapeutic effects in various medical conditions, including sepsis, acute respiratory distress syndrome (ARDS), and heart failure.
5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid, also known as leukotoxin A4 (LTA4), is a bioactive lipid mediator that plays a crucial role in inflammation and immune response. It is a member of the eicosanoid family of molecules, which are derived from arachidonic acid and other polyunsaturated fatty acids. LTA4 is synthesized by various cells, including leukocytes, platelets, and endothelial cells, and acts on a range of biological targets, including leukocytes, endothelial cells, and smooth muscle cells.