Acetyl tetrapeptide-9
Catalog Number: BT-257344
CAS Number: 928006-50-2
Molecular Formula: C22H33N7O9
Molecular Weight: 539.5 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction
Description
Acetyl tetrapeptide-9 is a synthetic peptide that has gained significant attention in the scientific community due to its potential therapeutic and industrial applications. It is a tetrapeptide composed of four amino acids, namely alanine, glutamic acid, aspartic acid, and arginine. Acetyl tetrapeptide-9 is known for its ability to improve skin elasticity, reduce wrinkles, and enhance skin hydration.
Properties
CAS Number
928006-50-2
Product Name
Acetyl tetrapeptide-9
IUPAC Name
(3S)-3-[[(2S)-2-acetamido-5-amino-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Molecular Formula
C22H33N7O9
Molecular Weight
539.5 g/mol
InChI
InChI=1S/C22H33N7O9/c1-10(2)18(21(36)28-15(22(37)38)6-12-8-24-9-25-12)29-20(35)14(7-17(32)33)27-19(34)13(26-11(3)30)4-5-16(23)31/h8-10,13-15,18H,4-7H2,1-3H3,(H2,23,31)(H,24,25)(H,26,30)(H,27,34)(H,28,36)(H,29,35)(H,32,33)(H,37,38)/t13-,14-,15-,18-/m0/s1
InChI Key
QNZANUZIBYJBIN-XSWJXKHESA-N
SMILES
CC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C
Solubility
Soluble in DMSO
Synonyms
Acetyl tetrapeptide-9; LS 9745; LS-9745; LS9745; N-Acetyl-gln-asp-val-his; Dermican;
Canonical SMILES
CC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C
Isomeric SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)C
Method of Synthesis or Extraction
Acetyl tetrapeptide-9 can be synthesized using solid-phase peptide synthesis (SPPS) or liquid-phase peptide synthesis (LPPS). SPPS is the most commonly used method for synthesizing peptides. It involves the sequential addition of amino acids to a solid support, which is usually a resin. The amino acids are protected by various chemical groups to prevent unwanted reactions. After the synthesis is complete, the peptide is cleaved from the resin and purified. LPPS, on the other hand, involves the synthesis of peptides in solution. The amino acids are activated with a coupling reagent and added to the growing peptide chain. The peptide is then purified using various chromatographic techniques.
The efficiency and yield of each method depend on several factors, such as the length and complexity of the peptide, the type of protecting groups used, and the purity of the starting materials. SPPS is generally more efficient and yields higher purity peptides than LPPS. However, SPPS is more expensive and time-consuming than LPPS. Environmental and safety considerations are also important when choosing a method of synthesis. SPPS generates less waste and is more environmentally friendly than LPPS. Both methods require the use of hazardous chemicals, and proper safety precautions should be taken.
The efficiency and yield of each method depend on several factors, such as the length and complexity of the peptide, the type of protecting groups used, and the purity of the starting materials. SPPS is generally more efficient and yields higher purity peptides than LPPS. However, SPPS is more expensive and time-consuming than LPPS. Environmental and safety considerations are also important when choosing a method of synthesis. SPPS generates less waste and is more environmentally friendly than LPPS. Both methods require the use of hazardous chemicals, and proper safety precautions should be taken.
Chemical Structure and Biological Activity
Acetyl tetrapeptide-9 has a molecular weight of 507.6 g/mol and a chemical formula of C22H35N7O7. It is a water-soluble peptide that can penetrate the skin barrier. Acetyl tetrapeptide-9 works by stimulating the production of collagen and elastin, which are essential proteins for maintaining skin elasticity and firmness. It also inhibits the activity of enzymes that break down collagen and elastin, thereby preventing skin aging.
Biological Effects
Acetyl tetrapeptide-9 has been shown to have several biological effects on cell function and signal transduction. It can improve skin hydration, reduce wrinkles, and enhance skin elasticity. It also has potential therapeutic effects in the treatment of skin aging, wound healing, and inflammatory skin conditions. However, acetyl tetrapeptide-9 may have potential toxic effects if used in high concentrations or for prolonged periods. It may cause skin irritation, allergic reactions, and other adverse effects.
Applications
Acetyl tetrapeptide-9 has several applications in medical, environmental, and industrial research. In medical research, it is used in drug development for the treatment of skin aging, wound healing, and inflammatory skin conditions. Clinical trials have shown promising results in improving skin elasticity and reducing wrinkles. However, further studies are needed to determine its long-term safety and efficacy.
In environmental research, acetyl tetrapeptide-9 is used to study its effects on ecosystems and its role in pollution management. It has been shown to have low toxicity and biodegradability, making it a potential candidate for sustainable and environmentally friendly products.
In industrial research, acetyl tetrapeptide-9 is used in manufacturing processes to improve product quality and efficiency. It is also used in the development of new cosmetic products for skin care. Health and safety considerations are important when using acetyl tetrapeptide-9 in industrial applications.
In environmental research, acetyl tetrapeptide-9 is used to study its effects on ecosystems and its role in pollution management. It has been shown to have low toxicity and biodegradability, making it a potential candidate for sustainable and environmentally friendly products.
In industrial research, acetyl tetrapeptide-9 is used in manufacturing processes to improve product quality and efficiency. It is also used in the development of new cosmetic products for skin care. Health and safety considerations are important when using acetyl tetrapeptide-9 in industrial applications.
Future Perspectives and Challenges
The use of acetyl tetrapeptide-9 in scientific research is still limited by several challenges. One of the main challenges is the lack of long-term safety data. Further studies are needed to determine its potential toxic effects and long-term safety. Another challenge is the high cost of synthesis, which limits its widespread use in industrial applications. Future research should focus on developing more efficient and cost-effective methods of synthesis.
Conclusion:
Acetyl tetrapeptide-9 is a promising peptide with potential therapeutic and industrial applications. Its ability to improve skin elasticity, reduce wrinkles, and enhance skin hydration makes it a valuable ingredient in cosmetic products. However, further studies are needed to determine its long-term safety and efficacy. The development of more efficient and cost-effective methods of synthesis will also be crucial for its widespread use in industrial applications.
Conclusion:
Acetyl tetrapeptide-9 is a promising peptide with potential therapeutic and industrial applications. Its ability to improve skin elasticity, reduce wrinkles, and enhance skin hydration makes it a valuable ingredient in cosmetic products. However, further studies are needed to determine its long-term safety and efficacy. The development of more efficient and cost-effective methods of synthesis will also be crucial for its widespread use in industrial applications.
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