Agathisflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-6 and C-8 of the two chromene rings. It has a role as an antineoplastic agent, an antiviral agent, a hepatoprotective agent and a metabolite. It is a biflavonoid, a hydroxyflavone and a biaryl.
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AB-928 is an adenosine A2A and A2B receptor dual antagonist. It inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro. AB-928, alone or in combination with doxorubicin, reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model. AB928 is a dual antagonist of the A2aR and A2bR adenosine receptors, leads to greater immune activation and reduced tumor growth when combined with chemotherapy
2-Acetamido-1,2-Dideoxynojirmycin (ADNM) is a natural product that belongs to the class of aminoglycoside antibiotics. It was first isolated from the fermentation broth of Streptomyces nodosus in 1987. Since then, ADNM has been the subject of extensive research due to its potent antibacterial and antitumor activities.
Abacavir carboxylate is a nucleoside reverse transcriptase inhibitor (NRTI) used in the treatment of human immunodeficiency virus (HIV) infection. It is a prodrug of abacavir, which is converted to its active form in the body. Abacavir carboxylate has been shown to be effective in reducing viral load and increasing CD4+ T-cell counts in HIV-infected patients.
Abafungin is a natural product that belongs to the class of cyclic lipopeptides. It is produced by the fungus Verticillium sp. and has been found to possess potent antifungal activity. Abafungin has been the subject of extensive research due to its potential therapeutic applications in the treatment of fungal infections. This paper aims to provide an overview of abafungin, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.
Ziagen is a medication used to treat HIV infection. It belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). Ziagen is also known by its generic name, abacavir. It was approved by the US Food and Drug Administration (FDA) in 1998 and is currently used in combination with other antiretroviral drugs to treat HIV.
Abamectin is a natural product derived from the soil bacterium Streptomyces avermitilis. It belongs to the class of macrocyclic lactones and is widely used as an insecticide and acaricide in agriculture. Abamectin has also shown potential in medical and environmental research due to its unique chemical structure and biological activity.
Abaloparatide (brand name Tymlos) is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis. Like the related drug teriparatide, and unlike bisphosphonates, it is an anabolic (i.e., bone growing) agent. In 2017, it was approved to treat postmenopausal osteoporosis in the United States.