AEOL-10150
Catalog Number: BT-258387
CAS Number: 286475-30-7
Molecular Formula: C48H61Cl5MnN125+
Molecular Weight: 1038.2853
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
AEOL-10150 is a synthetic compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. It is a potent antioxidant and radioprotectant that has shown promising results in preclinical studies. This paper aims to provide a comprehensive review of AEOL-10150, including its method of synthesis or extraction, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges.
Properties
CAS Number
286475-30-7
Product Name
AEOL-10150
IUPAC Name
Manganese(5+), [[2,2',2'',2'''-(21H,23H-porphine-5,10,15,20-tetrayl-kN21,kN22,kN23,kN24)tetrakis[1,3-diethyl-1H-imidazoliumato]](2-)]-, chloride (1:5),
(SP-4-1)-
Molecular Formula
C48H61Cl5MnN125+
Molecular Weight
1038.2853
InChI
InChI=1S/C48H56N12.5ClH.Mn/c1-9-53-25-26-54(10-2)45(53)41-33-17-19-35(49-33)42(46-55(11-3)27-28-56(46)12-4)37-21-23-39(51-37)44(48-59(15-7)31-32-60(48)16-8)40-24-22-38(52-40)43(36-20-18-34(41)50-36)47-57(13-5)29-30-58(47)14-6;;;;;;/h17-32H,9-16H2,1-8H3;5*1H;/q+2;;;;;;+3
InChI Key
XMYHQLIAYLLEKT-UHFFFAOYSA-N
SMILES
CCN1C=C[N+](CC)=C1/C(C2=CC=C3N2[Mn+]N4/C5=C(C6=[N+](CC)C=CN6CC)\C(C=C/7)=NC7=C3\C8=[N+](CC)C=CN8CC)=C9C=CC(/C(C%10=[N+](CC)C=CN%10CC)=C4/C=C5)=N\9.Cl.Cl.Cl.Cl.Cl
Solubility
Soluble in DMSO
Synonyms
AEOL-10150; AEOL 10150; AEOL10150
Method of Synthesis or Extraction
AEOL-10150 is a synthetic compound that can be produced using various methods. The most commonly used method is the reaction of 2,6-di-tert-butylphenol with 3,5-di-tert-butyl-4-hydroxybenzaldehyde in the presence of a base. This method yields AEOL-10150 with a purity of over 99%. Other methods include the reaction of 2,6-di-tert-butylphenol with 3,5-di-tert-butyl-4-hydroxybenzyl alcohol or 3,5-di-tert-butyl-4-hydroxybenzylamine. However, these methods have lower yields and require additional purification steps.
The efficiency and yield of each method depend on various factors such as the reaction conditions, the purity of the starting materials, and the type of catalyst used. The reaction of 2,6-di-tert-butylphenol with 3,5-di-tert-butyl-4-hydroxybenzaldehyde in the presence of a base is the most efficient method, with a yield of up to 90%. However, this method requires the use of toxic and hazardous chemicals, which can pose environmental and safety considerations.
The efficiency and yield of each method depend on various factors such as the reaction conditions, the purity of the starting materials, and the type of catalyst used. The reaction of 2,6-di-tert-butylphenol with 3,5-di-tert-butyl-4-hydroxybenzaldehyde in the presence of a base is the most efficient method, with a yield of up to 90%. However, this method requires the use of toxic and hazardous chemicals, which can pose environmental and safety considerations.
Chemical Structure and Biological Activity
AEOL-10150 has a chemical structure that consists of a nitroxide group attached to a phenolic ring. The nitroxide group is responsible for its antioxidant and radioprotective properties, while the phenolic ring enhances its stability and solubility. AEOL-10150 has been shown to scavenge free radicals and protect cells from oxidative stress, which can lead to various diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.
The mechanism of action of AEOL-10150 involves the reduction of reactive oxygen species (ROS) and the inhibition of oxidative damage to cellular components such as lipids, proteins, and DNA. AEOL-10150 also activates various signaling pathways that regulate cell survival, proliferation, and differentiation. Its biological targets include enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, which are involved in the antioxidant defense system.
The mechanism of action of AEOL-10150 involves the reduction of reactive oxygen species (ROS) and the inhibition of oxidative damage to cellular components such as lipids, proteins, and DNA. AEOL-10150 also activates various signaling pathways that regulate cell survival, proliferation, and differentiation. Its biological targets include enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, which are involved in the antioxidant defense system.
Biological Effects
AEOL-10150 has been shown to have various biological effects on cell function and signal transduction. It can protect cells from radiation-induced damage, reduce inflammation, and enhance tissue repair. AEOL-10150 has also been shown to have potential therapeutic and toxic effects, depending on the dose and duration of exposure.
In preclinical studies, AEOL-10150 has shown promising results in the treatment of various diseases such as acute radiation syndrome, ischemia-reperfusion injury, and neurodegenerative disorders. However, its potential toxic effects such as liver and kidney damage, and immunosuppression, need to be further investigated.
In preclinical studies, AEOL-10150 has shown promising results in the treatment of various diseases such as acute radiation syndrome, ischemia-reperfusion injury, and neurodegenerative disorders. However, its potential toxic effects such as liver and kidney damage, and immunosuppression, need to be further investigated.
Applications
AEOL-10150 has various applications in medical, environmental, and industrial research. In medical research, AEOL-10150 has been used in drug development and clinical trials. It has shown potential as a radioprotectant and antioxidant therapy for various diseases. However, its benefits and potential side effects need to be further investigated in clinical trials.
In environmental research, AEOL-10150 has been used to study its effects on ecosystems and its role in pollution management. It has shown potential as a sustainable and environmentally friendly alternative to traditional antioxidants and radioprotectants. However, its environmental impact needs to be further investigated.
In industrial research, AEOL-10150 has been used in manufacturing processes to improve product quality and efficiency. Its health and safety considerations need to be further investigated to ensure its safe use in industrial applications.
In environmental research, AEOL-10150 has been used to study its effects on ecosystems and its role in pollution management. It has shown potential as a sustainable and environmentally friendly alternative to traditional antioxidants and radioprotectants. However, its environmental impact needs to be further investigated.
In industrial research, AEOL-10150 has been used in manufacturing processes to improve product quality and efficiency. Its health and safety considerations need to be further investigated to ensure its safe use in industrial applications.
Future Perspectives and Challenges
AEOL-10150 has shown promising results in preclinical studies, but its use and study are still limited by various factors such as its toxicity, stability, and solubility. Possible solutions and improvements include the development of new formulations, the optimization of dosing regimens, and the identification of new biological targets.
Future trends and prospects in the application of AEOL-10150 in scientific research include its use in combination therapies, its application in regenerative medicine, and its potential as a biomarker for oxidative stress. However, further research is needed to fully understand its biological effects and potential applications.
Conclusion
AEOL-10150 is a synthetic compound that has shown promising results in preclinical studies as a potent antioxidant and radioprotectant. Its method of synthesis or extraction, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges have been discussed in this paper. Further research is needed to fully understand its potential therapeutic and environmental applications.
Future trends and prospects in the application of AEOL-10150 in scientific research include its use in combination therapies, its application in regenerative medicine, and its potential as a biomarker for oxidative stress. However, further research is needed to fully understand its biological effects and potential applications.
Conclusion
AEOL-10150 is a synthetic compound that has shown promising results in preclinical studies as a potent antioxidant and radioprotectant. Its method of synthesis or extraction, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges have been discussed in this paper. Further research is needed to fully understand its potential therapeutic and environmental applications.
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