Altanserin hydrochloride is a chemical compound that belongs to the class of serotonin receptor antagonists. It is a potent and selective antagonist of the 5-HT2A receptor, which is involved in various physiological and pathological processes. Altanserin hydrochloride has been extensively studied for its potential therapeutic applications in various diseases, including schizophrenia, depression, anxiety, and Parkinson's disease.

Alteminostat is a histone deacetylase inhibitor and antineoplastic drug candidate.

Altanserin tartrate is a compound that binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain.

Alternariol monomethyl ether (AME) is a mycotoxin produced by the Alternaria fungi. It is commonly found in food and feed crops, such as cereals, fruits, and vegetables, and has been shown to have toxic effects on human and animal health. In recent years, AME has gained attention in scientific research due to its potential therapeutic and industrial applications. This paper aims to provide an overview of AME, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges. Method of Synthesis or Extraction AME can be synthesized or extracted from Alternaria fungi using various methods. The most common method of synthesis involves the reaction of alternariol with diazomethane, which results in the formation of AME. The yield of this method is relatively low, ranging from 10-20%, and it requires the use of hazardous chemicals, such as diazomethane, which poses a risk to the environment and human health. Other methods of synthesis include the use of enzymes and microorganisms, which have shown to be more efficient and environmentally friendly. The extraction of AME from Alternaria fungi can be achieved using various solvents, such as methanol, ethanol, and acetone. The efficiency of extraction depends on the type of solvent used, the extraction time, and the temperature. Methanol has been shown to be the most efficient solvent for AME extraction, with a yield of up to 90%. However, the use of organic solvents poses a risk to the environment and human health, and alternative methods, such as supercritical fluid extraction, are being explored. Chemical Structure and Biological Activity AME has a chemical structure similar to that of alternariol, with the addition of a methyl group. It has been shown to have various biological activities, including cytotoxic, genotoxic, and immunotoxic effects. AME has been found to induce DNA damage and inhibit cell proliferation in vitro. It has also been shown to have immunosuppressive effects, inhibiting the production of cytokines and chemokines. Biological Effects AME has been shown to have various effects on cell function and signal transduction. It has been found to induce oxidative stress and activate various signaling pathways, such as the MAPK and NF-κB pathways. AME has also been shown to have potential therapeutic and toxic effects. It has been found to have anti-inflammatory and anti-tumor properties, making it a potential candidate for drug development. However, it has also been shown to have toxic effects on human and animal health, such as liver and kidney damage. Applications AME has various applications in scientific research, including medical, environmental, and industrial research. In medical research, AME has been studied for its potential role in drug development. It has been found to have anti-inflammatory and anti-tumor properties, making it a potential candidate for the treatment of various diseases, such as cancer and inflammatory disorders. Clinical trials are currently underway to investigate the safety and efficacy of AME in humans. In environmental research, AME has been studied for its effects on ecosystems and its role in pollution management. It has been found to have toxic effects on aquatic organisms, such as fish and algae, and can accumulate in the food chain. AME has also been studied for its potential use in bioremediation, as it has been shown to degrade certain pollutants. In industrial research, AME has been studied for its use in manufacturing processes and improving product quality and efficiency. It has been found to have antimicrobial properties, making it a potential candidate for use in food preservation. However, the use of AME in industrial applications poses a risk to human and environmental health, and safety considerations must be taken into account. Future Perspectives and Challenges Despite the potential applications of AME in scientific research, there are current limitations in its use and study. The low yield and efficiency of synthesis methods, as well as the use of hazardous chemicals, pose challenges to its production and use. The toxic effects of AME on human and animal health also pose challenges to its use in medical and industrial applications. Possible solutions and improvements include the use of alternative synthesis methods, such as enzymatic and microbial synthesis, and the development of safer and more efficient extraction methods. Further research is also needed to fully understand the biological effects and potential therapeutic applications of AME. In conclusion, AME is a mycotoxin produced by the Alternaria fungi that has gained attention in scientific research due to its potential therapeutic and industrial applications. Its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges have been discussed in this paper. Further research is needed to fully understand the potential of AME in scientific research and its impact on human and environmental health.