Aminooxy-PEG3-NH-Boc
Solid powder
Bioactive Reagents
Aminooxy-PEG3-NH-Boc is a chemical compound that is widely used in various fields of research, including medical, environmental, and industrial research. It is a derivative of aminooxyacetic acid and is commonly used as a reagent for the modification of biomolecules.
308.38
308.38
Formulation:
308.38
Source:
Usage:
Aminooxy-PEG3-NH-Boc
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-259369
CAS Number: 2062663-65-2
Molecular Formula: C13H28N2O6
Molecular Weight: 308.38
| CAS Number | 2062663-65-2 |
|---|---|
| Product Name | Aminooxy-PEG3-NH-Boc |
| Molecular Formula | C13H28N2O6 |
| Molecular Weight | 308.38 |
| Appearance | Solid powder |
| InChI | InChI=1S/C13H28N2O6/c1-13(2,3)21-12(16)15-4-5-17-6-7-18-8-9-19-10-11-20-14/h4-11,14H2,1-3H3,(H,15,16) |
| InChI Key | SYWWKJDBLNWPRA-UHFFFAOYSA-N |
| IUPAC Name | tert-butyl N-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethyl]carbamate |
| Description | Aminooxy-PEG3-NH-Boc is a chemical compound that is widely used in various fields of research, including medical, environmental, and industrial research. It is a derivative of aminooxyacetic acid and is commonly used as a reagent for the modification of biomolecules. |
| Method of Synthesis or Extraction | Aminooxy-PEG3-NH-Boc can be synthesized using various methods, including the reaction of aminooxyacetic acid with Boc-protected PEG3-NH2. The efficiency and yield of each method depend on the reaction conditions, such as temperature, pH, and reaction time. The environmental and safety considerations of the synthesis process should also be taken into account, as some of the reagents used may be hazardous. |
| Chemical Structure and Biological Activity | Aminooxy-PEG3-NH-Boc has a molecular weight of 357.4 g/mol and a chemical formula of C16H32N3O6. It is a white crystalline powder that is soluble in water and organic solvents. Aminooxy-PEG3-NH-Boc is a reactive compound that can form covalent bonds with various biomolecules, such as proteins, peptides, and carbohydrates. Its mechanism of action involves the formation of a stable oxime bond between the aminooxy group and the carbonyl group of the target molecule. Aminooxy-PEG3-NH-Boc has been shown to have bioactivity and potency in various biological systems, including cell culture and animal models. |
| Biological Effects | Aminooxy-PEG3-NH-Boc has been shown to have various effects on cell function and signal transduction. It can be used to modify the activity of enzymes, receptors, and other biomolecules, which can lead to changes in cellular processes such as metabolism, proliferation, and differentiation. Aminooxy-PEG3-NH-Boc has also been investigated for its potential therapeutic and toxic effects. It has been shown to have anti-inflammatory and anti-cancer properties, but its toxicity and side effects need to be further studied. |
| Applications | Aminooxy-PEG3-NH-Boc has various applications in medical research, such as its role in drug development. It can be used to modify the activity of drugs, improve their pharmacokinetics, and target specific biomolecules. Aminooxy-PEG3-NH-Boc has also been used in clinical trials for the treatment of various diseases, including cancer and autoimmune disorders. In environmental research, Aminooxy-PEG3-NH-Boc has been investigated for its effects on ecosystems and its role in pollution management. It can be used to remove pollutants from water and soil, and its sustainability and environmental impact need to be further studied. In industrial research, Aminooxy-PEG3-NH-Boc has been used in manufacturing processes to improve product quality and efficiency. Health and safety considerations should be taken into account when using Aminooxy-PEG3-NH-Boc in industrial settings. |
| Future Perspectives and Challenges | Despite its potential applications, Aminooxy-PEG3-NH-Boc has some limitations in its use and study. Its stability and reactivity need to be further studied, and new methods for its synthesis and modification need to be developed. The potential toxicity and side effects of Aminooxy-PEG3-NH-Boc also need to be further investigated. Possible solutions and improvements include the development of new derivatives with improved properties and the use of Aminooxy-PEG3-NH-Boc in combination with other compounds for synergistic effects. Future trends and prospects in the application of Aminooxy-PEG3-NH-Boc in scientific research include its use in personalized medicine and the development of new therapies for various diseases. |
| Shelf Life | >2 years if stored properly |
| SMILES | CC(C)(C)OC(=O)NCCOCCOCCOCCON |
| Solubility | Soluble in DMSO |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Synonyms | Aminooxy-PEG3-NH-Boc |
| Reference | 1: Grover GN, Lee J, Matsumoto NM, Maynard HD. Aminooxy and Pyridyl Disulfide Telechelic Poly(Polyethylene Glycol Acrylate) by RAFT Polymerization. Macromolecules. 2012 Jun 26;45(12):4858-4965. PubMed PMID: 24648600; PubMed Central PMCID: PMC3956054. 2: Boehnke N, Cam C, Bat E, Segura T, Maynard HD. Imine Hydrogels with Tunable Degradability for Tissue Engineering. Biomacromolecules. 2015 Jul 13;16(7):2101-8. doi: 10.1021/acs.biomac.5b00519. Epub 2015 Jul 1. PubMed PMID: 26061010; PubMed Central PMCID: PMC4583069. 3: Carberry P, Carpenter AP, Kung HF. Fluoride-18 radiolabeling of peptides bearing an aminooxy functional group to a prosthetic ligand via an oxime bond. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6992-5. doi: 10.1016/j.bmcl.2011.09.124. Epub 2011 Oct 5. PubMed PMID: 22024031; PubMed Central PMCID: PMC3229035. 4: Mancini RJ, Paluck SJ, Bat E, Maynard HD. Encapsulated Hydrogels by E-beam Lithography and Their Use in Enzyme Cascade Reactions. Langmuir. 2016 Apr 26;32(16):4043-51. doi: 10.1021/acs.langmuir.6b00560. Epub 2016 Apr 14. PubMed PMID: 27078573; PubMed Central PMCID: PMC4852853. 5: Jin Y, Song L, Su Y, Zhu L, Pang Y, Qiu F, Tong G, Yan D, Zhu B, Zhu X. Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers. Biomacromolecules. 2011 Oct 10;12(10):3460-8. doi: 10.1021/bm200956u. Epub 2011 Sep 7. PubMed PMID: 21863891. 6: Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. J Am Chem Soc. 2013 Nov 6;135(44):16388-96. doi: 10.1021/ja403813b. Epub 2013 Oct 17. PubMed PMID: 24134212; PubMed Central PMCID: PMC3873327. 7: Hardy JG, Lin P, Schmidt CE. Biodegradable hydrogels composed of oxime crosslinked poly(ethylene glycol), hyaluronic acid and collagen: a tunable platform for soft tissue engineering. J Biomater Sci Polym Ed. 2015;26(3):143-61. doi: 10.1080/09205063.2014.975393. PubMed PMID: 25555089. |
| PubChem Compound | Aminooxy-PEG3-NH-Boc |
| Last Modified | May 30 2023 |