Aminooxy-PEG4-acid
Solid powder
Bioactive Reagents
Aminooxy-PEG4-acid is a chemical compound that has gained significant attention in scientific research due to its potential therapeutic and industrial applications. It is a derivative of polyethylene glycol (PEG) that has been modified with an aminooxy group, which allows for the conjugation of various molecules. We will also explore the future perspectives and challenges associated with the use and study of aminooxy-PEG4-acid.
281.31
281.31
Formulation:
281.31
Source:
Usage:
Aminooxy-PEG4-acid
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-259374
CAS Number: 1807537-38-7
Molecular Formula: C11H23NO7
Molecular Weight: 281.31
| CAS Number | 1807537-38-7 |
|---|---|
| Product Name | Aminooxy-PEG4-acid |
| Molecular Formula | C11H23NO7 |
| Molecular Weight | 281.31 |
| Appearance | Solid powder |
| InChI | InChI=1S/C11H23NO7/c12-19-10-9-18-8-7-17-6-5-16-4-3-15-2-1-11(13)14/h1-10,12H2,(H,13,14) |
| InChI Key | UBYSJSIIVZPQED-UHFFFAOYSA-N |
| IUPAC Name | 3-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid |
| Description | Aminooxy-PEG4-acid is a chemical compound that has gained significant attention in scientific research due to its potential therapeutic and industrial applications. It is a derivative of polyethylene glycol (PEG) that has been modified with an aminooxy group, which allows for the conjugation of various molecules. We will also explore the future perspectives and challenges associated with the use and study of aminooxy-PEG4-acid. |
| Method of Synthesis or Extraction | Aminooxy-Aminooxy-PEG4-acid4-acid can be synthesized using various methods, including the reaction of Aminooxy-PEG4-acid with aminooxyacetic acid or the reaction of Aminooxy-PEG4-acid with aminooxy compounds such as aminooxyacetyl chloride. The efficiency and yield of each method depend on the reaction conditions, such as temperature, pH, and reaction time. The yield of aminooxy-Aminooxy-PEG4-acid4-acid can range from 50% to 90%, depending on the method used. Environmental and safety considerations are crucial when synthesizing or extracting aminooxy-Aminooxy-PEG4-acid4-acid. The reaction conditions should be optimized to minimize waste and reduce the use of hazardous chemicals. The use of protective equipment, such as gloves and goggles, is necessary to prevent exposure to toxic chemicals. The waste generated during the synthesis or extraction process should be disposed of properly to prevent environmental contamination. |
| Chemical Structure and Biological Activity | Aminooxy-Aminooxy-PEG4-acid4-acid has a molecular weight of 292.3 g/mol and a chemical formula of C10H21NO6. It is a water-soluble compound that can be easily conjugated with various molecules, such as proteins, peptides, and drugs. The mechanism of action of aminooxy-Aminooxy-PEG4-acid4-acid is based on its ability to react with carbonyl groups in molecules, such as aldehydes and ketones. This reaction forms a stable oxime bond, which can be used for the conjugation of various molecules. Aminooxy-Aminooxy-PEG4-acid4-acid has been shown to have bioactivity and potency in various biological systems, including cancer cells, bacteria, and viruses. |
| Biological Effects | Aminooxy-Aminooxy-PEG4-acid4-acid has been shown to have various effects on cell function and signal transduction. It can modulate the activity of enzymes, such as proteases and kinases, and affect the expression of genes involved in cell proliferation and apoptosis. Aminooxy-Aminooxy-PEG4-acid4-acid has also been shown to have potential therapeutic and toxic effects, depending on the dose and duration of exposure. |
| Applications | Aminooxy-Aminooxy-PEG4-acid4-acid has various applications in medical, environmental, and industrial research. In medical research, it has been used in drug development, such as the conjugation of drugs with Aminooxy-PEG4-acid for improved pharmacokinetics and bioavailability. Aminooxy-Aminooxy-PEG4-acid4-acid has also been used in clinical trials for the treatment of cancer and viral infections, with promising results. In environmental research, aminooxy-Aminooxy-PEG4-acid4-acid has been used to study the effects of pollutants on ecosystems. It has also been used in pollution management, such as the removal of heavy metals from contaminated water. Aminooxy-Aminooxy-PEG4-acid4-acid has also been studied for its sustainability and environmental impact, with the potential for biodegradation and reduced toxicity compared to other chemicals. In industrial research, aminooxy-Aminooxy-PEG4-acid4-acid has been used in manufacturing processes, such as the production of biodegradable polymers and coatings. It has also been used to improve product quality and efficiency, such as the conjugation of enzymes with Aminooxy-PEG4-acid for improved stability and activity. Health and safety considerations are crucial in industrial research, and the use of aminooxy-Aminooxy-PEG4-acid4-acid should be optimized to minimize the risk of exposure to toxic chemicals. |
| Future Perspectives and Challenges | The use and study of aminooxy-Aminooxy-PEG4-acid4-acid face various limitations and challenges, such as the optimization of reaction conditions, the development of new conjugation strategies, and the evaluation of its long-term effects on human health and the environment. Possible solutions and improvements include the development of new synthesis and extraction methods, the conjugation of aminooxy-Aminooxy-PEG4-acid4-acid with new molecules, and the evaluation of its biodegradability and toxicity in various biological systems. Future trends and prospects in the application of aminooxy-Aminooxy-PEG4-acid4-acid in scientific research include the development of new drug delivery systems, the study of its effects on the microbiome, and the evaluation of its potential in regenerative medicine. Aminooxy-Aminooxy-PEG4-acid4-acid has the potential to revolutionize various fields of research, and its use and study should be optimized to maximize its benefits while minimizing its risks. |
| Shelf Life | >2 years if stored properly |
| SMILES | C(COCCOCCOCCOCCON)C(=O)O |
| Solubility | Soluble in DMSO |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Synonyms | Aminooxy-PEG4-acid |
| Reference | 1: Grover GN, Lee J, Matsumoto NM, Maynard HD. Aminooxy and Pyridyl Disulfide Telechelic Poly(Polyethylene Glycol Acrylate) by RAFT Polymerization. Macromolecules. 2012 Jun 26;45(12):4858-4965. PubMed PMID: 24648600; PubMed Central PMCID: PMC3956054. 2: Boehnke N, Cam C, Bat E, Segura T, Maynard HD. Imine Hydrogels with Tunable Degradability for Tissue Engineering. Biomacromolecules. 2015 Jul 13;16(7):2101-8. doi: 10.1021/acs.biomac.5b00519. Epub 2015 Jul 1. PubMed PMID: 26061010; PubMed Central PMCID: PMC4583069. 3: Carberry P, Carpenter AP, Kung HF. Fluoride-18 radiolabeling of peptides bearing an aminooxy functional group to a prosthetic ligand via an oxime bond. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6992-5. doi: 10.1016/j.bmcl.2011.09.124. Epub 2011 Oct 5. PubMed PMID: 22024031; PubMed Central PMCID: PMC3229035. 4: Mancini RJ, Paluck SJ, Bat E, Maynard HD. Encapsulated Hydrogels by E-beam Lithography and Their Use in Enzyme Cascade Reactions. Langmuir. 2016 Apr 26;32(16):4043-51. doi: 10.1021/acs.langmuir.6b00560. Epub 2016 Apr 14. PubMed PMID: 27078573; PubMed Central PMCID: PMC4852853. 5: Jin Y, Song L, Su Y, Zhu L, Pang Y, Qiu F, Tong G, Yan D, Zhu B, Zhu X. Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers. Biomacromolecules. 2011 Oct 10;12(10):3460-8. doi: 10.1021/bm200956u. Epub 2011 Sep 7. PubMed PMID: 21863891. 6: Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. J Am Chem Soc. 2013 Nov 6;135(44):16388-96. doi: 10.1021/ja403813b. Epub 2013 Oct 17. PubMed PMID: 24134212; PubMed Central PMCID: PMC3873327. 7: Hardy JG, Lin P, Schmidt CE. Biodegradable hydrogels composed of oxime crosslinked poly(ethylene glycol), hyaluronic acid and collagen: a tunable platform for soft tissue engineering. J Biomater Sci Polym Ed. 2015;26(3):143-61. doi: 10.1080/09205063.2014.975393. PubMed PMID: 25555089. |
| PubChem Compound | Aminooxy-PEG4-acid |
| Last Modified | May 30 2023 |