Dapiprazole, also known as rev-eyes or remydrial, belongs to the class of organic compounds known as phenylpiperazines. Phenylpiperazines are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group. Dapiprazole is a drug which is used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. Dapiprazole is considered to be a practically insoluble (in water) and relatively neutral molecule. Dapiprazole has been detected in multiple biofluids, such as urine and blood. Within the cell, dapiprazole is primarily located in the membrane (predicted from logP). Dapiprazole is a N-arylpiperazine, a N-alkylpiperazine and a member of pyridines. It has a role as an alpha-adrenergic antagonist, a miotic, an ophthalmology drug and an antipsychotic agent. Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
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Dapiprazole hydrochloride is a medication used to treat certain eye conditions such as mydriasis and cycloplegia. It is a selective alpha-1 adrenergic receptor antagonist that works by blocking the action of norepinephrine, a neurotransmitter that causes the dilation of the pupil. Dapiprazole hydrochloride is also being studied for its potential therapeutic effects in other medical conditions and its role in environmental and industrial research.
Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis--a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM)-- and inhibit the growth of lung cancer cells in anchorage-independent condition. Preliminary data obtained discloses the inhibitory effect on cancer cell metastasis of the isolated compounds and may provide a new approach for cancer drug development.
Chromium picolinate is a chemical compound that is widely used as a dietary supplement due to its potential health benefits. It is a combination of chromium and picolinic acid, which is a natural chelator that helps to improve the absorption of chromium in the body. Chromium picolinate has been studied extensively for its potential therapeutic effects, including its role in regulating blood sugar levels, improving insulin sensitivity, and reducing inflammation.
Chrysobactin is a catechol-type siderophore with a structure of D-lysyl-L-serine substituted on N(2) of the lysyl residue by a 2,3-dihydroxybenzoyl group. It is produced by the Gram-negative bacillus Dickeya dadantii (previously known as Erwinia chrysanthem). Only the catecholate hydroxyl groups participate in metal coordination, so chrysobactin cannot provide full 1:1 coordination of Fe(III); at neutral pH and concentrations of about 0.1 mM, ferric chrysobactin exists as a mixture of bis and tris complexes. It has a role as a siderophore and a bacterial metabolite. It is a member of catechols, a dipeptide, a monocarboxylic acid, a primary alcohol and a primary amino compound.
CHS-111 is a benzyl indazole compound which inhibits superoxide anion (O(2)(-)) generation. CHS-111 also reduced the fMLP- but not phorbol ester-stimulated PLD activity (IC(50) 3.9±1.2μM). CHS-111 inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells.
2-[6-(4-Chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine, also known as CPG-37157, is a small molecule compound that has gained significant attention in the scientific community due to its potential therapeutic and environmental applications. This paper aims to provide a comprehensive overview of the synthesis, chemical structure, biological activity, and potential applications of CPG-37157.