Dapt
Catalog Number: BT-264450
CAS Number: 208255-80-5
Molecular Formula: C23H26F2N2O4
Molecular Weight: 432.5 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
Dapt is a chemical compound that has gained significant attention in scientific research due to its potential therapeutic and environmental applications. It is a member of the class of compounds known as beta-lactam antibiotics, which are widely used in the treatment of bacterial infections. Dapt is unique in its structure and mode of action, making it a promising candidate for the development of new drugs and environmental management strategies. In this paper, we will explore the synthesis and extraction methods of Dapt, its chemical structure and biological activity, its effects on cell function and signal transduction, and its potential applications in medical, environmental, and industrial research. We will also discuss the current limitations and future prospects of Dapt in scientific research.
Properties
CAS Number
208255-80-5
Product Name
Dapt
IUPAC Name
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Molecular Formula
C23H26F2N2O4
Molecular Weight
432.5 g/mol
InChI
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChI Key
DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
Solubility
Soluble in DMSO, not in water
Synonyms
DAPT; DAPT peptide; GSI-IX; GSI IX; N-(2FPhAc)Ala-phenyl-Gly t-butyl ester.
Canonical SMILES
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
Method of Synthesis or Extraction
Dapt can be synthesized using a variety of methods, including chemical synthesis and fermentation. Chemical synthesis involves the reaction of various chemical compounds to produce Dapt. The efficiency and yield of this method depend on the purity of the starting materials, the reaction conditions, and the expertise of the chemist. Fermentation, on the other hand, involves the use of microorganisms to produce Dapt. This method is more environmentally friendly and can yield higher quantities of Dapt. However, it requires specialized equipment and expertise.
Environmental and safety considerations are important when synthesizing or extracting Dapt. Chemical synthesis can produce hazardous waste and byproducts, which must be disposed of properly to prevent environmental contamination. Fermentation requires the use of living organisms, which must be handled carefully to prevent contamination and ensure their safety.
Environmental and safety considerations are important when synthesizing or extracting Dapt. Chemical synthesis can produce hazardous waste and byproducts, which must be disposed of properly to prevent environmental contamination. Fermentation requires the use of living organisms, which must be handled carefully to prevent contamination and ensure their safety.
Chemical Structure and Biological Activity
Dapt has a unique chemical structure that distinguishes it from other beta-lactam antibiotics. It contains a cyclic lipopeptide ring that is attached to a beta-lactam ring. This structure allows Dapt to bind to and disrupt the cell membrane of bacteria, leading to their death.
Dapt has a broad spectrum of activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It has also shown activity against some Gram-negative bacteria, although its effectiveness is limited in this regard.
Dapt has a broad spectrum of activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It has also shown activity against some Gram-negative bacteria, although its effectiveness is limited in this regard.
Biological Effects
Dapt's mechanism of action involves binding to the bacterial cell membrane and disrupting its integrity. This leads to the leakage of cellular contents and ultimately, bacterial death. Dapt also affects cell signaling pathways, leading to changes in gene expression and cellular function.
Dapt has potential therapeutic and toxic effects. Its ability to kill bacteria makes it a promising candidate for the treatment of bacterial infections. However, its effects on cell signaling pathways may also have unintended consequences, leading to toxicity and adverse effects.
Dapt has potential therapeutic and toxic effects. Its ability to kill bacteria makes it a promising candidate for the treatment of bacterial infections. However, its effects on cell signaling pathways may also have unintended consequences, leading to toxicity and adverse effects.
Applications
Dapt has potential applications in medical, environmental, and industrial research. In medical research, Dapt's role in drug development is being explored, with several clinical trials underway to test its effectiveness against various bacterial infections. Its benefits and potential side effects are being studied to determine its safety and efficacy.
In environmental research, Dapt's effects on ecosystems and its role in pollution management are being investigated. Its potential impact on sustainability and the environment is also being studied.
In industrial research, Dapt's use in manufacturing processes is being explored, with a focus on improving product quality and efficiency. Health and safety considerations are also being taken into account to ensure the safe use of Dapt in industrial settings.
In environmental research, Dapt's effects on ecosystems and its role in pollution management are being investigated. Its potential impact on sustainability and the environment is also being studied.
In industrial research, Dapt's use in manufacturing processes is being explored, with a focus on improving product quality and efficiency. Health and safety considerations are also being taken into account to ensure the safe use of Dapt in industrial settings.
Future Perspectives and Challenges
Despite its potential applications, there are limitations to the use and study of Dapt. Its effectiveness against Gram-negative bacteria is limited, and its toxicity and adverse effects must be carefully studied to ensure its safety. Possible solutions and improvements include the development of new derivatives of Dapt that are more effective against Gram-negative bacteria and have fewer adverse effects.
Future trends and prospects in the application of Dapt in scientific research include the continued exploration of its potential therapeutic and environmental applications. The development of new methods for synthesizing and extracting Dapt may also lead to increased efficiency and yield. However, careful consideration must be given to the environmental and safety implications of these methods.
Conclusion:
Dapt is a promising compound with potential applications in medical, environmental, and industrial research. Its unique chemical structure and mode of action make it a promising candidate for the development of new drugs and environmental management strategies. However, careful consideration must be given to its toxicity and adverse effects, as well as its environmental and safety implications. Further research is needed to fully explore the potential of Dapt in scientific research.
Future trends and prospects in the application of Dapt in scientific research include the continued exploration of its potential therapeutic and environmental applications. The development of new methods for synthesizing and extracting Dapt may also lead to increased efficiency and yield. However, careful consideration must be given to the environmental and safety implications of these methods.
Conclusion:
Dapt is a promising compound with potential applications in medical, environmental, and industrial research. Its unique chemical structure and mode of action make it a promising candidate for the development of new drugs and environmental management strategies. However, careful consideration must be given to its toxicity and adverse effects, as well as its environmental and safety implications. Further research is needed to fully explore the potential of Dapt in scientific research.
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