Dids
Catalog Number: BT-264487
CAS Number: 67483-13-0
Molecular Formula: C16H8N2Na2O6S4
Molecular Weight: 498.5 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
Price:
Product Introduction
Description
Dids, also known as 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid, is a chemical compound that has gained significant attention in scientific research due to its unique properties and potential applications. Dids is a fluorescent molecule that is commonly used as a probe to study membrane transport and ion channels. In addition, it has been found to have potential therapeutic and environmental applications. This paper will provide an overview of the methods of synthesis or extraction of Dids, its chemical structure and biological activity, its biological effects, and its applications in medical, environmental, and industrial research. Finally, the paper will discuss future perspectives and challenges in the use and study of Dids.
Properties
CAS Number
67483-13-0
Product Name
Dids
IUPAC Name
disodium;5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate
Molecular Formula
C16H8N2Na2O6S4
Molecular Weight
498.5 g/mol
InChI
InChI=1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;;
InChI Key
GEPAYBXVXXBSKP-SEPHDYHBSA-L
SMILES
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
Solubility
Soluble in DMSO
Synonyms
4,4'-Diisothiocyano-2,2'-Stilbene Disulfonic Acid
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
DIDS
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
DIDS
Canonical SMILES
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
Isomeric SMILES
C1=CC(=C(C=C1N=C=S)S(=O)(=O)[O-])/C=C/C2=C(C=C(C=C2)N=C=S)S(=O)(=O)[O-].[Na+].[Na+]
Method of Synthesis or Extraction
Dids can be synthesized using a variety of methods, including the reaction of Dids'-diaminostilbene-2,2'-disulfonic acid with thiophosgene or the reaction of Dids'-diaminostilbene-2,2'-disulfonic acid with phosgene and thionyl chloride. The yield and efficiency of these methods vary depending on the reaction conditions and the purity of the starting materials. In addition, these methods can produce hazardous byproducts and require careful handling and disposal to ensure environmental and safety considerations.
Chemical Structure and Biological Activity
Dids has a unique chemical structure that consists of two stilbene moieties connected by a disulfonic acid group. This structure gives Dids its fluorescent properties and allows it to interact with membrane transporters and ion channels. Dids has been found to inhibit the activity of the Na+/H+ exchanger and the Cl^-/HCO3^- exchanger, which are important for regulating pH and ion balance in cells. In addition, Dids has been shown to modulate the activity of several ion channels, including the cystic fibrosis transmembrane conductance regulator (CFTR) and the voltage-gated potassium channel (Kv1.3). These effects on ion transport and channel activity make Dids a valuable tool for studying membrane transport and ion channel function.
Biological Effects
The effects of Dids on cell function and signal transduction depend on the specific membrane transporters and ion channels that it interacts with. Inhibition of the Na+/H+ exchanger and the Cl^-/HCO3^- exchanger can lead to changes in intracellular pH and ion balance, which can affect cell proliferation, migration, and apoptosis. Modulation of ion channel activity can affect membrane potential and neurotransmitter release, which can impact neuronal signaling and synaptic plasticity. In addition, Dids has been found to have potential therapeutic and toxic effects. For example, Dids has been shown to inhibit the growth of cancer cells and to protect against ischemic injury in the heart and brain. However, Dids can also induce oxidative stress and apoptosis in some cell types, which can lead to tissue damage and inflammation.
Applications
Dids has a wide range of applications in scientific research, including medical, environmental, and industrial research. In medical research, Dids has been used to study the function of membrane transporters and ion channels, as well as to develop new drugs that target these proteins. For example, Dids has been used to screen for compounds that can modulate the activity of CFTR, which is defective in cystic fibrosis. In addition, Dids has been used in clinical trials to evaluate the efficacy of drugs that target ion channels, such as Kv1.3 inhibitors for the treatment of autoimmune diseases. However, the potential side effects of Dids on cell function and toxicity must be carefully considered in the development of new drugs.
In environmental research, Dids has been used to study the effects of pollutants on membrane transport and ion channel function in aquatic organisms. For example, Dids has been used to investigate the effects of heavy metals on the activity of Na+/H+ exchangers in fish gills. In addition, Dids has been used in pollution management to monitor the transport of pollutants in water and soil. However, the environmental impact of Dids and its byproducts must be carefully evaluated to ensure sustainability and minimize harm to ecosystems.
In industrial research, Dids has been used to improve product quality and efficiency in manufacturing processes. For example, Dids has been used to monitor the transport of ions and molecules in membrane filtration systems for water treatment and food processing. In addition, Dids has been used to evaluate the health and safety considerations of industrial chemicals and products. However, the potential hazards of Dids and its byproducts must be carefully managed to ensure worker safety and minimize environmental impact.
In environmental research, Dids has been used to study the effects of pollutants on membrane transport and ion channel function in aquatic organisms. For example, Dids has been used to investigate the effects of heavy metals on the activity of Na+/H+ exchangers in fish gills. In addition, Dids has been used in pollution management to monitor the transport of pollutants in water and soil. However, the environmental impact of Dids and its byproducts must be carefully evaluated to ensure sustainability and minimize harm to ecosystems.
In industrial research, Dids has been used to improve product quality and efficiency in manufacturing processes. For example, Dids has been used to monitor the transport of ions and molecules in membrane filtration systems for water treatment and food processing. In addition, Dids has been used to evaluate the health and safety considerations of industrial chemicals and products. However, the potential hazards of Dids and its byproducts must be carefully managed to ensure worker safety and minimize environmental impact.
Future Perspectives and Challenges
Despite the potential applications of Dids in scientific research, there are several limitations and challenges that must be addressed. For example, the specificity and selectivity of Dids for membrane transporters and ion channels can vary depending on the experimental conditions and the cell type. In addition, the potential toxicity and side effects of Dids on cell function and signaling must be carefully evaluated in the development of new drugs and industrial products. Finally, the environmental impact of Dids and its byproducts must be carefully managed to ensure sustainability and minimize harm to ecosystems. Future research should focus on developing new methods for synthesizing and extracting Dids, as well as improving its specificity and selectivity for membrane transporters and ion channels. In addition, future research should investigate the potential therapeutic and environmental applications of Dids, as well as the potential hazards and safety considerations of its use.
Product FAQ
Q1: How Can I Obtain a Quote for a Product I'm Interested In?
- To receive a quotation, send us an inquiry about the desired product.
- The quote will cover pack size options, pricing, and availability details.
- If applicable, estimated lead times for custom synthesis or sourcing will be provided.
- Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
- New customers generally require full prepayment.
- NET 30 payment terms can be arranged for customers with established credit.
- Contact our customer service to set up a credit account for NET 30 terms.
- We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
- Preferred methods include bank transfers (ACH/wire) and credit cards.
- Request a proforma invoice for bank transfer details.
- For credit card payments, ask sales representatives for a secure payment link.
- Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
- Orders are confirmed upon receiving official order requests.
- Provide full prepayment or submit purchase orders for credit account customers.
- Send purchase orders to sales@thebiotek.com.
- A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
- Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
- You can use your FedEx account; specify this on the purchase order or inform customer service.
- Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
- Reach out to our customer service representatives at sales@thebiotek.com.
- For ongoing order updates or questions, continue using the same email.
- Remember, we're here to help! Feel free to contact us for any queries or further assistance.
Quick Inquiry
Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.
Category
Hot Products
D-ribose-L-cysteine
CAS No.: 232617-15-1
Sterubin
CAS No.: 51857-11-5
Troparil, (+)-
CAS No.: 74163-84-1
![N-Phenyl-d5-N'-[1-(2-phenylethyl)]-4-piperidine](/images/structure/BT-1439938.png)
N-Phenyl-d5-N'-[1-(2-phenylethyl)]-4-piperidine
CAS No.: 1189466-15-6
POE (15) tallow amine
CAS No.: 61791-26-2
5-Cholesten-3beta-25-diol-3-sulfate
CAS No.: 884905-07-1
info@thebiotek.com
256 N Vinedo Ave, Pasadena, California 91107
