2'-Deoxycytidine-5'-triphosphate trisodium salt
Catalog Number: BT-265277
CAS Number: 109909-44-6
Molecular Formula: C9H16N3O13P3
Molecular Weight: 467.15693
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
2'-Deoxycytidine-5'-triphosphate trisodium salt (dCTP) is a nucleotide that plays a crucial role in DNA synthesis and repair. It is a building block of DNA and is essential for the maintenance of genetic information. dCTP is synthesized in the body through a complex biochemical pathway involving several enzymes. It is also available commercially and is widely used in medical, environmental, and industrial research.
Properties
CAS Number
109909-44-6
Product Name
2'-Deoxycytidine-5'-triphosphate trisodium salt
IUPAC Name
trisodium;[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate
Molecular Formula
C9H16N3O13P3
Molecular Weight
467.15693
InChI
InChI=1S/C9H16N3O13P3.3Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17);;;/q;3*+1/p-3/t5-,6+,8+;;;/m0.../s1
InChI Key
WBIPTAOOMJEGQO-MILVPLDLSA-K
SMILES
C1C(C(OC1N2C=CC(=NC2=O)N)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O.[Na+].[Na+].[Na+]
Solubility
Soluble in DMSO, not in water
Synonyms
dCTP Thymus; Cytidine 5(tetrahydrogen triphosphate) 2deoxy trisodium salt; Cytidine 2deoxy 5(tetrahydrogen triphosphate) trisodium salt; Cytidine 2deoxy triphosphate trisodium salt; 2DeoxyCTP trisodium salt; 2Deoxycytidine 5triphosphate trisodium salt; 5DCTP trisodium salt; Deoxy5CTPtrisodium salt; DeoxyCTP trisodium salt; Deoxycytidine 5triphosphate trisodium salt; Deoxycytidine triphosphate trisodium salt.
Method of Synthesis or Extraction
DCTP can be synthesized using several methods, including enzymatic synthesis, chemical synthesis, and fermentation. Enzymatic synthesis involves the use of enzymes to catalyze the reaction between cytosine and triphosphate. Chemical synthesis involves the use of chemical reagents to synthesize 2'-Deoxycytidine-5'-triphosphate trisodium salt. Fermentation involves the use of microorganisms to produce 2'-Deoxycytidine-5'-triphosphate trisodium salt. Each method has its advantages and disadvantages in terms of efficiency, yield, and environmental and safety considerations.
Enzymatic synthesis is the most efficient method for producing 2'-Deoxycytidine-5'-triphosphate trisodium salt, with a yield of up to 90%. It is also environmentally friendly and does not produce toxic waste. However, it is expensive and requires specialized equipment and expertise. Chemical synthesis is less efficient, with a yield of up to 50%, but it is cheaper and easier to scale up. However, it produces toxic waste and requires careful handling to avoid environmental contamination. Fermentation is the least efficient method, with a yield of up to 30%, but it is the most environmentally friendly and sustainable. However, it requires a long fermentation time and is not suitable for large-scale production.
Enzymatic synthesis is the most efficient method for producing 2'-Deoxycytidine-5'-triphosphate trisodium salt, with a yield of up to 90%. It is also environmentally friendly and does not produce toxic waste. However, it is expensive and requires specialized equipment and expertise. Chemical synthesis is less efficient, with a yield of up to 50%, but it is cheaper and easier to scale up. However, it produces toxic waste and requires careful handling to avoid environmental contamination. Fermentation is the least efficient method, with a yield of up to 30%, but it is the most environmentally friendly and sustainable. However, it requires a long fermentation time and is not suitable for large-scale production.
Chemical Structure and Biological Activity
DCTP is a nucleotide composed of a cytosine base, a deoxyribose sugar, and three phosphate groups. It is structurally similar to other nucleotides, such as dATP, dGTP, and dTTP, and plays a crucial role in DNA synthesis and repair. 2'-Deoxycytidine-5'-triphosphate trisodium salt is incorporated into the growing DNA chain by DNA polymerase and is essential for the maintenance of genetic information.
Biological Effects
DCTP has several biological effects on cell function and signal transduction. It is involved in DNA replication, repair, and recombination and is essential for the proper functioning of the cell cycle. 2'-Deoxycytidine-5'-triphosphate trisodium salt also plays a role in signal transduction pathways, such as the MAPK/ERK pathway, and is involved in the regulation of gene expression.
2'-Deoxycytidine-5'-triphosphate trisodium salt has potential therapeutic and toxic effects. It is used in medical research for the development of antiviral and anticancer drugs. However, it can also be toxic to cells and can cause DNA damage and mutations.
2'-Deoxycytidine-5'-triphosphate trisodium salt has potential therapeutic and toxic effects. It is used in medical research for the development of antiviral and anticancer drugs. However, it can also be toxic to cells and can cause DNA damage and mutations.
Applications
DCTP has several applications in medical, environmental, and industrial research. In medical research, 2'-Deoxycytidine-5'-triphosphate trisodium salt is used in drug development, clinical trials, and findings. It is also used in the diagnosis of genetic disorders and in gene therapy. In environmental research, 2'-Deoxycytidine-5'-triphosphate trisodium salt is used to study the effects of pollutants on ecosystems and to develop sustainable solutions for pollution management. In industrial research, 2'-Deoxycytidine-5'-triphosphate trisodium salt is used in manufacturing processes to improve product quality and efficiency. Health and safety considerations are important in all applications of 2'-Deoxycytidine-5'-triphosphate trisodium salt.
Future Perspectives and Challenges
The use and study of 2'-Deoxycytidine-5'-triphosphate trisodium salt face several limitations, including the high cost of enzymatic synthesis, the toxicity of chemical synthesis, and the low yield of fermentation. Possible solutions and improvements include the development of new enzymatic and chemical synthesis methods and the optimization of fermentation conditions. Future trends and prospects in the application of 2'-Deoxycytidine-5'-triphosphate trisodium salt in scientific research include the development of new drugs and therapies for genetic disorders and cancer and the use of 2'-Deoxycytidine-5'-triphosphate trisodium salt in the development of sustainable solutions for pollution management.
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