Buy Flumethasone (BT-268298)

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Flumethasone

Catalog Number: BT-268298

CAS Number: 2135-17-3

Molecular Formula: C22H28F2O5

Molecular Weight: 410.5 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Flumethasone is a synthetic glucocorticoid that is widely used in medical, environmental, and industrial research. It is a potent anti-inflammatory and immunosuppressive agent that has been used in the treatment of various inflammatory and autoimmune diseases. Flumethasone is also used in environmental research to study its effects on ecosystems and pollution management. In industrial research, it is used in manufacturing processes to improve product quality and efficiency. This paper aims to provide a comprehensive review of flumethasone, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.

Properties

CAS Number

2135-17-3

Product Name

Flumethasone

IUPAC Name

(6S,9R,10S,11S,13S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Molecular Formula

C22H28F2O5

Molecular Weight

410.5 g/mol

InChI

InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13?,14?,16+,17+,19+,20+,21+,22+/m1/s1

InChI Key

WXURHACBFYSXBI-DRBBXQFKSA-N

SMILES

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

Solubility

Soluble in DMSO.

Synonyms

69difluoro1117 21trihydroxy16methylpregna14diene320dione 1721diacetate

Canonical SMILES

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

Isomeric SMILES

C[C@@H]1CC2C3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F

Method of Synthesis or Extraction

Flumethasone is synthesized by the reaction of 6α-fluoro-16α-methylprednisolone with acetic anhydride in the presence of a catalyst. The yield of this method is around 70%, and the process is relatively efficient. However, the use of acetic anhydride as a reagent can be hazardous to the environment and human health. Alternative methods of synthesis include the reaction of 6α-fluoro-16α-methylprednisolone with trifluoroacetic anhydride or trifluoroacetic acid. These methods have a higher yield of around 90%, but they also have environmental and safety considerations.

Chemical Structure and Biological Activity

Flumethasone has a chemical structure similar to other glucocorticoids, with a 21-carbon skeleton and a ketone group at position 3. It binds to the glucocorticoid receptor and regulates gene expression, leading to its anti-inflammatory and immunosuppressive effects. Flumethasone has a high potency and a long duration of action, making it an effective treatment for various inflammatory and autoimmune diseases.

Biological Effects

Flumethasone has a wide range of biological effects on cell function and signal transduction. It inhibits the production of pro-inflammatory cytokines and chemokines, reduces the migration of immune cells to sites of inflammation, and suppresses the activation of T cells and B cells. Flumethasone also has potential therapeutic and toxic effects, depending on the dose and duration of treatment. It can cause side effects such as osteoporosis, diabetes, and adrenal suppression.

Applications

In medical research, flumethasone has been used in drug development and clinical trials for various inflammatory and autoimmune diseases, such as rheumatoid arthritis, asthma, and inflammatory bowel disease. It has shown promising results in reducing inflammation and improving symptoms in these diseases. However, its potential side effects need to be carefully monitored. In environmental research, flumethasone has been studied for its effects on ecosystems and pollution management. It has been found to have toxic effects on aquatic organisms and can accumulate in the environment. In industrial research, flumethasone is used in manufacturing processes to improve product quality and efficiency. Health and safety considerations need to be taken into account when handling flumethasone in industrial settings.

Future Perspectives and Challenges

The use of flumethasone in medical, environmental, and industrial research is likely to continue in the future. However, there are current limitations in its use and study, such as its potential side effects and environmental impact. Possible solutions and improvements include the development of safer and more effective glucocorticoids, the use of alternative methods of synthesis or extraction, and the implementation of sustainable practices in industrial settings. Future trends and prospects in the application of flumethasone in scientific research will depend on these developments and the continued evaluation of its benefits and risks.
Conclusion:
Flumethasone is a synthetic glucocorticoid that has been widely used in medical, environmental, and industrial research. Its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges have been reviewed in this paper. Flumethasone has shown promising results in the treatment of various inflammatory and autoimmune diseases, but its potential side effects and environmental impact need to be carefully monitored. The development of safer and more effective glucocorticoids and the implementation of sustainable practices in industrial settings are important for the future application of flumethasone in scientific research.

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